methioninen.

Brit.

/mᵻˈθʌɪəniːn/,

/mᵻˈθʌɪənɪn/, U.S.

/məˈθaɪəˌnin/,

/məˈθaɪənən/

Origin: Formed within English, by derivation. Etymons: methyl n., thio- comb. form, -ine suffix⁵.

Etymology: < me- (in methyl n.) + thio- comb. form + -n- (perhaps euphonic, or influenced by the name of the betaine derivative of histidine ergothioneine) + -ine suffix⁵.

Biochemistry.

An essential amino acid with a hydrophobic, sulphur-containing side chain; 2-amino-4-(methylthio)butanoic acid, CH₃·S·CH₂·CH₂·CH(NH₂)·COOH.

ΚΠ

1928 G. Barger & F. P. Coyne in Biochem. Jrnl. 22 1418 Since the amino-acid has a good title to be regarded as a constituent of protein, a shorter name than γ-methylthiol-α-aminobutyric acid seems desirable, and..we suggest for it the name methionine, in allusion to the characteristic grouping.

1947 Nucleonics Dec. 11/1 Labeled ethylene was obtained by Du Vigneaud..for his preparation of methionine.

1956 Nature 11 Feb. 280/1 The amino-acid requirement of this organism [sc. a flagellate] could be satisfied by methionine alone.

1968 New Eng. Jrnl. Med. 14 Mar. 590/1 A genetically determined disorder of methionine metabolism.

1972 McGraw-Hill Yearbk. Sci. & Technol. 123/1 Since methionine is the only metabolic precursor of homocysteine in the human diet, deliberate reduction in the amount of dietary animal protein, which contains more methionine than plant protein, may prove to be effective in preventing arteriosclerosis.

1988 Vitamin Connection May–June 22/3 Deficiency of methionine has been implicated in low resistance to disease and build-up of fat in the liver.

1996 Independent 10 Dec. ii. 11/4 A ‘safe’ version of paracetamol, in which it is combined with methionine,..is at present causing controversy.

Compounds

methionine-enkephalin n. the enkephalin that terminates in a methionine residue; = met-enkephalin n.

ΚΠ

1975 J. Hughes et al. in Nature 18 Dec. 578/2 The mass spectrum of natural enkephalin is therefore interpreted as being the result of a mixture of the two pentapeptides H-Tyr-Gly-Gly-Phe-Met-OH (methionine-enkephalin) and H-Tyr-Gly-Gly-Phe-Leu-OH (leucine-enkephalin).

1982 Science 25 June 1427/1 (note) We found a significant negative correlation between the amount of ethanol consumed in four different inbred strains of mice and methionine-enkephalin content in whole brains.

1996 Guardian 7 Nov. i. 17/3 Named methionine and leucine enkephalin, this pair of peptides marked a watershed in pharmacology.

This entry has been updated (OED Third Edition, December 2001; most recently modified version published online March 2022).

单词	methionine
释义	methioninen. Brit. /mᵻˈθʌɪəniːn/, /mᵻˈθʌɪənɪn/, U.S. /məˈθaɪəˌnin/, /məˈθaɪənən/ Origin: Formed within English, by derivation. Etymons: methyl n., thio- comb. form, -ine suffix⁵. Etymology: < me- (in methyl n.) + thio- comb. form + -n- (perhaps euphonic, or influenced by the name of the betaine derivative of histidine ergothioneine) + -ine suffix⁵. Biochemistry. An essential amino acid with a hydrophobic, sulphur-containing side chain; 2-amino-4-(methylthio)butanoic acid, CH₃·S·CH₂·CH₂·CH(NH₂)·COOH. ΚΠ 1928 G. Barger & F. P. Coyne in Biochem. Jrnl. 22 1418 Since the amino-acid has a good title to be regarded as a constituent of protein, a shorter name than γ-methylthiol-α-aminobutyric acid seems desirable, and..we suggest for it the name methionine, in allusion to the characteristic grouping. 1947 Nucleonics Dec. 11/1 Labeled ethylene was obtained by Du Vigneaud..for his preparation of methionine. 1956 Nature 11 Feb. 280/1 The amino-acid requirement of this organism [sc. a flagellate] could be satisfied by methionine alone. 1968 New Eng. Jrnl. Med. 14 Mar. 590/1 A genetically determined disorder of methionine metabolism. 1972 McGraw-Hill Yearbk. Sci. & Technol. 123/1 Since methionine is the only metabolic precursor of homocysteine in the human diet, deliberate reduction in the amount of dietary animal protein, which contains more methionine than plant protein, may prove to be effective in preventing arteriosclerosis. 1988 Vitamin Connection May–June 22/3 Deficiency of methionine has been implicated in low resistance to disease and build-up of fat in the liver. 1996 Independent 10 Dec. ii. 11/4 A ‘safe’ version of paracetamol, in which it is combined with methionine,..is at present causing controversy. Compounds methionine-enkephalin n. the enkephalin that terminates in a methionine residue; = met-enkephalin n. ΚΠ 1975 J. Hughes et al. in Nature 18 Dec. 578/2 The mass spectrum of natural enkephalin is therefore interpreted as being the result of a mixture of the two pentapeptides H-Tyr-Gly-Gly-Phe-Met-OH (methionine-enkephalin) and H-Tyr-Gly-Gly-Phe-Leu-OH (leucine-enkephalin). 1982 Science 25 June 1427/1 (note) We found a significant negative correlation between the amount of ethanol consumed in four different inbred strains of mice and methionine-enkephalin content in whole brains. 1996 Guardian 7 Nov. i. 17/3 Named methionine and leucine enkephalin, this pair of peptides marked a watershed in pharmacology. This entry has been updated (OED Third Edition, December 2001; most recently modified version published online March 2022). < n.1928
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