metaplasian.

Brit.

/ˌmɛtəˈpleɪzɪə/,

/ˌmɛtəˈpleɪʒə/, U.S.

/ˌmɛdəˈpleɪʒ(i)ə/,

/ˌmɛdəˈpleɪziə/

Origin: Formed within English, by derivation; perhaps modelled on a German lexical item, or perhaps modelled on a French lexical item. Etymons: meta- prefix, -plasia comb. form.

Etymology: < meta- prefix + -plasia comb. form, after German Metaplasie (R. Virchow: see note below) or French métaplasie (1869 in a translation of Virchow). Compare ancient Greek μεταπλάσσειν to mould into a new form. In sense 2 after German myeloiden Metaplasie (1913); compare French métaplasie médullaire (1921). Compare hyperplasia n.German Metaplasie was first used by Rudolph (Carl) Virchow (1821–1902), German pathologist, physician and statesman, in a lecture on the theory of cellular pathology given at the University of Berlin in 1858.

1. Pathology. Transformation of one type of differentiated tissue into another.

ΘΚΠ

the world > life > biology > biological processes > development, growth, or degeneration > [noun] > transformation of tissue

transformation1834

metamorphosis1844

metabolism1872

metaplasia1883

1883 D. MacAlister tr. E. Ziegler Text-bk. Pathol. Anat. I. xx. 130 A tissue is said to undergo metaplasia when it is transformed into another of a diverse kind.

1890 New Sydenham Soc. Lexicon (at cited word) Cartilage is transformed into mucoid or areolar tissue, or into bone, by undergoing metaplasia.

1896 T. C. Allbutt et al. Syst. Med. I. 202 Among normal tissues a transformation of one variety into another..has received from Virchow the distinctive name of metaplasia.

1923 Jrnl. Pathol. & Bacteriol. 26 399 (title) Heteromorphoses (metaplasia) of the alimentary tract.

1949 H. W. C. Vines Green's Man. Pathol. (ed. 17) viii. 168 Metaplasia in epithelia usually implies a change to the keratinised squamous type.

1967 Canad. Med. Assoc. Jrnl. 15 July 143/2 Contrasting metaplasia as an acquired transformation with the heteroplasia of embryonic tissues, he demonstrated the occurrence of epithelial and connective metaplasia in varied tumours.

1993 Brit. Jrnl. Surg. 80 58/2 Disease progressed from normal mucosa through intestinal metaplasia to carcinoma.

2. Medicine myeloid metaplasia n. (originally) extramedullary haematopoiesis; (later also) a syndrome characterized by fibrosis of the bone marrow with anaemia, presence of misshapen and immature blood cells in the circulation, and prominent extramedullary haematopoiesis, esp. in the spleen and liver.

ΘΚΠ

the world > health and disease > ill health > a disease > disorders of internal organs > disorders of blood > [noun] > other blood disorders

diacrisis1684

melanaema1788

mal-crasis1854

saturation1872

myeloid metaplasia1931

abetalipoproteinaemia1960

acanthocytosis1960

myelodysplasia1966

1931 Amer. Jrnl. Med. Sci. 181 451 Myeloid metaplasia has been produced experimentally by many workers.

1938 F. J. Lang in H. Downey Handbk. Hematol. III. 2105 (note) The term ‘myeloid metaplasia’ is used in the broad sense to include the appearance outside the bone marrow of progenitors of the several types of blood cells; ‘extramedullary hematopoiesis’ is perhaps a clearer designation.

1957 Amer. Jrnl. Med. 22 107/1 Extramedullary hemopoiesis or myeloid metaplasia due to unknown cause which is frequently associated with myelofibrosis or osteosclerosis.

1980 Lancet 19 Jan. 127/1 The condition known to British haematologists as idiopathic myelofibrosis and to their American colleagues as agnogenic myeloid metaplasia.

1999 Blood Rev. 13 163 Morbidity from myeloid metaplasia and myelofibrosis arises from progressive anemia and abdominal discomfort related to massive splenomegaly.

This entry has been updated (OED Third Edition, December 2001; most recently modified version published online March 2022).

单词	metaplasia
释义	metaplasian. Brit. /ˌmɛtəˈpleɪzɪə/, /ˌmɛtəˈpleɪʒə/, U.S. /ˌmɛdəˈpleɪʒ(i)ə/, /ˌmɛdəˈpleɪziə/ Origin: Formed within English, by derivation; perhaps modelled on a German lexical item, or perhaps modelled on a French lexical item. Etymons: meta- prefix, -plasia comb. form. Etymology: < meta- prefix + -plasia comb. form, after German Metaplasie (R. Virchow: see note below) or French métaplasie (1869 in a translation of Virchow). Compare ancient Greek μεταπλάσσειν to mould into a new form. In sense 2 after German myeloiden Metaplasie (1913); compare French métaplasie médullaire (1921). Compare hyperplasia n.German Metaplasie was first used by Rudolph (Carl) Virchow (1821–1902), German pathologist, physician and statesman, in a lecture on the theory of cellular pathology given at the University of Berlin in 1858. 1. Pathology. Transformation of one type of differentiated tissue into another. ΘΚΠ the world > life > biology > biological processes > development, growth, or degeneration > [noun] > transformation of tissue transformation1834 metamorphosis1844 metabolism1872 metaplasia1883 1883 D. MacAlister tr. E. Ziegler Text-bk. Pathol. Anat. I. xx. 130 A tissue is said to undergo metaplasia when it is transformed into another of a diverse kind. 1890 New Sydenham Soc. Lexicon (at cited word) Cartilage is transformed into mucoid or areolar tissue, or into bone, by undergoing metaplasia. 1896 T. C. Allbutt et al. Syst. Med. I. 202 Among normal tissues a transformation of one variety into another..has received from Virchow the distinctive name of metaplasia. 1923 Jrnl. Pathol. & Bacteriol. 26 399 (title) Heteromorphoses (metaplasia) of the alimentary tract. 1949 H. W. C. Vines Green's Man. Pathol. (ed. 17) viii. 168 Metaplasia in epithelia usually implies a change to the keratinised squamous type. 1967 Canad. Med. Assoc. Jrnl. 15 July 143/2 Contrasting metaplasia as an acquired transformation with the heteroplasia of embryonic tissues, he demonstrated the occurrence of epithelial and connective metaplasia in varied tumours. 1993 Brit. Jrnl. Surg. 80 58/2 Disease progressed from normal mucosa through intestinal metaplasia to carcinoma. 2. Medicine myeloid metaplasia n. (originally) extramedullary haematopoiesis; (later also) a syndrome characterized by fibrosis of the bone marrow with anaemia, presence of misshapen and immature blood cells in the circulation, and prominent extramedullary haematopoiesis, esp. in the spleen and liver. ΘΚΠ the world > health and disease > ill health > a disease > disorders of internal organs > disorders of blood > [noun] > other blood disorders diacrisis1684 melanaema1788 mal-crasis1854 saturation1872 myeloid metaplasia1931 abetalipoproteinaemia1960 acanthocytosis1960 myelodysplasia1966 1931 Amer. Jrnl. Med. Sci. 181 451 Myeloid metaplasia has been produced experimentally by many workers. 1938 F. J. Lang in H. Downey Handbk. Hematol. III. 2105 (note) The term ‘myeloid metaplasia’ is used in the broad sense to include the appearance outside the bone marrow of progenitors of the several types of blood cells; ‘extramedullary hematopoiesis’ is perhaps a clearer designation. 1957 Amer. Jrnl. Med. 22 107/1 Extramedullary hemopoiesis or myeloid metaplasia due to unknown cause which is frequently associated with myelofibrosis or osteosclerosis. 1980 Lancet 19 Jan. 127/1 The condition known to British haematologists as idiopathic myelofibrosis and to their American colleagues as agnogenic myeloid metaplasia. 1999 Blood Rev. 13 163 Morbidity from myeloid metaplasia and myelofibrosis arises from progressive anemia and abdominal discomfort related to massive splenomegaly. This entry has been updated (OED Third Edition, December 2001; most recently modified version published online March 2022). < n.1883
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