mestranoln.
/ˈmɛstrənɒl/, U.S. /ˈmɛstrəˌnɔl/, /ˈmɛstrəˌnɑl/ Pharmacology.
A synthetic oestrogen used chiefly in oral contraceptives, in combination with a progestational agent; the 3-methyl ether of ethynyloestradiol, C21H26O2.
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norethisterone1956
norethynodrel1957
mestranol1962
1962 Approved Names (Brit. Pharmacopœia Comm.) 15 Mestranol.
1963 Federation Proc. (Federation Amer. Soc. Exper. Biol.) 22 481 A 2-year..test was conducted..to determine the safety of Ortho-Novum, an oral contraceptive preparation containing norethindrone..and mestranol..in a ratio of 1,000 to 6.
1971 Brit. Med. Bull. 27 26/1 No difference could be detected between the risks associated with two different types of oestrogen (mestranol and ethynyloestradiol [sic]) when used in the same dose.
1987 M. J. Neal Med. Pharmacol. at Glance xxx. 67/2 Only two oestrogens are used: mestranol and ethinyloestradiol.
1997 Jrnl. Clin. Pharmacol. 37 193 Mestranol, the estrogen component of some oral contraceptive formulations, must be demethylated to its active metabolite, 17 alpha-ethinyl estradiol, to produce estrogenic activity.
This entry has been updated (OED Third Edition, September 2001; most recently modified version published online March 2022).
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n.1962