1835 Rep. Brit. Assoc., Sections 42 The sulpho-methylate of potash.]

1852 Jrnl. Chem. Soc. 4 232 Three-carbon ether, Ethylate of methyle, or Methylate of ethyle.——This compound may be prepared by the action of iodide of ethyle on the methylate of sodium.

1880 Athenæum 27 Nov. 713/1 The authors..have thus prepared aluminic methylate, ethylate, propylate (isopropylate could not be obtained).

1954 Jrnl. Amer. Chem. Soc. 76 1456/1 Deacetylation of I [sc. 9α-fluorohydrocortisone acetate] with sodium methylate afforded 9α-fluorohydrocortisone.

1955 Chem. & Engin. News 7 Mar. 1015/1 Jensen prefers ethylate, methylate, and phenolate to ethoxide, methoxide, and phenoxide... The first decennial index to CA [sc. Chemical Abstracts] used the -ylate and -olate terms, but changed to -oxide in Vols. 15 and 16.., perhaps to conform with British practice.

1991 Lancaster Catal. 1991/92 (MTM Res. Chemicals Ltd.) 1156 Sodium methoxide (Sodium methylate).

2000 Jrnl. Chromatogr. A. 873 129 The direct extraction of the methyl arsenic compounds by SPME [= solid-phase microextraction] after thioglycol methylate derivatization was studied.

1851 A. W. Hofmann in Philos. Trans. (Royal Soc.) 141 376 As I had some grammes of diethylamylamine at my disposal, I preferred to methylate this compound.

1888 Jrnl. Chem. Soc. 53 778 An attempt was made to methylate acetyl-metanitranilide by the action of sodium ethylate and methyl iodide.

1917 Jrnl. Chem. Soc. 111 848 Experiments have proved the wide scope of the use of formaldehyde for methylating amino-compounds.

1967 I. L. Finar Org. Chem. (ed. 5) I. xxvi. 683 Veratrole..may be prepared by methylating catechol with methyl sulphate in alkaline solution.

1990 Carcinogenesis 11 1301/2 Methionine can be synthesized by the body from choline, a precursor of betaine that can methylate homocysteine to form ethionine.

1864 Ladies' Repository Apr. 247/2 In the last session of the British Parliament an act was passed allowing spirit of wine to be methylated duty free.

1880 Act 43 & 44 Vict. c. 24 §3 ‘Methylate’ means to mix spirits with some substance in such manner as to render the mixture unfit for use as a beverage.

1906 Science 16 Feb. 280/1 The commission for the methods of examining and methylating alcohol, appointed by the French government.

1915 Science 16 July 99/2 (heading) Dimethylsulfate as a methylating agent.

1929 Jrnl. Amer. Chem. Soc. 51 2535 We have found methyl bromide to be a satisfactory methylating agent with both malonic ester and acetoacetic ester.

1975 Clin. Chem. 21 751/1 We describe a modification of the MacGee method for rapid determination of phenytoin (diphenylhydantoin) in plasma by gas-liquid chromatography, in which an ethylating reagent is used instead of the more common methylating reagents.

1995 Nature 12 Oct. 481/1 The assumption has been that the analogous dication (CH₃)₃OH²⁺ is a methylating species.