methylationn.

Brit.

/ˌmɛθᵻˈleɪʃn/, U.S.

/ˌmɛθəˈleɪʃ(ə)n/

Origin: Formed within English, by derivation. Etymons: methylate v., -ion suffix¹.

Etymology: < methylate v. + -ion suffix¹; compare -ation suffix.

1. Chemistry. The process of introducing one or more methyl groups into a compound; an instance of this. Also: the state of being methylated; the degree to which a compound is methylated.

ΘΚΠ

the world > matter > chemistry > organic chemistry > chemical processes or reactions > [noun] > methylation

methylation1863

1863 Proc. Royal Soc. 1862–3 12 642 Since only the last products of substitution presented any interest, I have submitted the two bases to methylation.

1880 Jrnl. Soc. Arts 445 The violets obtained by the methylation of rosaniline.

1922 J. J. Sudborough Bernthsen's Text-bk. Org. Chem. (new ed.) i. 57 It [sc. vinylacetylene] is formed from butadiine dibromide by the process of exhaustive methylation.

1951 Jrnl. Biol. Chem. 189 203 Methionine is the methyl donor for the methylation of both nicotinamide and guanidoacetic acid.

1963 Tetrahedron 19 1757 We had previously found that 6-methylation..enhances the anabolic-androgenic index of testosterone.

1984 M. J. Taussig Processes in Pathol. & Microbiol. (ed. 2) iv. 406 The high or low methylation state of MCPs is somehow transmitted to other proteins.

1992 C. A. Smith & E. J. Wood Biosynthesis vi. 126 Methylations, as for example, in the transfer of the methyl group of 5-methyltetrahydrofolate to homocysteine to form methionine.

2000 Nature 11 May 137/1 As in animals, DNA methylation in plants has been associated with genes that are silenced through their failure to be transcribed into RNA.

2. The addition of methanol to ethanol; the process of making methylated spirits. Now rare.

ΚΠ

1880 Act 43 & 44 Vict. c. 24 §83 Spirits warehoused may..be delivered out, without payment of duty, for methylation.

1891 Econ. Jrnl. 1 823 Another cause of decrease [in customs revenue] is due to the fall in the receipts from foreign spirits, hitherto used for the purposes of methylation.

1900 Jrnl. Royal Statist. Soc. 63 290 He would like to allude to one other point as to which there were no figures in the paper, viz., the methylation of spirits.

This entry has been updated (OED Third Edition, December 2001; most recently modified version published online March 2022).

单词	methylation
释义	methylationn. Brit. /ˌmɛθᵻˈleɪʃn/, U.S. /ˌmɛθəˈleɪʃ(ə)n/ Origin: Formed within English, by derivation. Etymons: methylate v., -ion suffix¹. Etymology: < methylate v. + -ion suffix¹; compare -ation suffix. 1. Chemistry. The process of introducing one or more methyl groups into a compound; an instance of this. Also: the state of being methylated; the degree to which a compound is methylated. ΘΚΠ the world > matter > chemistry > organic chemistry > chemical processes or reactions > [noun] > methylation methylation1863 1863 Proc. Royal Soc. 1862–3 12 642 Since only the last products of substitution presented any interest, I have submitted the two bases to methylation. 1880 Jrnl. Soc. Arts 445 The violets obtained by the methylation of rosaniline. 1922 J. J. Sudborough Bernthsen's Text-bk. Org. Chem. (new ed.) i. 57 It [sc. vinylacetylene] is formed from butadiine dibromide by the process of exhaustive methylation. 1951 Jrnl. Biol. Chem. 189 203 Methionine is the methyl donor for the methylation of both nicotinamide and guanidoacetic acid. 1963 Tetrahedron 19 1757 We had previously found that 6-methylation..enhances the anabolic-androgenic index of testosterone. 1984 M. J. Taussig Processes in Pathol. & Microbiol. (ed. 2) iv. 406 The high or low methylation state of MCPs is somehow transmitted to other proteins. 1992 C. A. Smith & E. J. Wood Biosynthesis vi. 126 Methylations, as for example, in the transfer of the methyl group of 5-methyltetrahydrofolate to homocysteine to form methionine. 2000 Nature 11 May 137/1 As in animals, DNA methylation in plants has been associated with genes that are silenced through their failure to be transcribed into RNA. 2. The addition of methanol to ethanol; the process of making methylated spirits. Now rare. ΚΠ 1880 Act 43 & 44 Vict. c. 24 §83 Spirits warehoused may..be delivered out, without payment of duty, for methylation. 1891 Econ. Jrnl. 1 823 Another cause of decrease [in customs revenue] is due to the fall in the receipts from foreign spirits, hitherto used for the purposes of methylation. 1900 Jrnl. Royal Statist. Soc. 63 290 He would like to allude to one other point as to which there were no figures in the paper, viz., the methylation of spirits. This entry has been updated (OED Third Edition, December 2001; most recently modified version published online March 2022). < n.1863
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