methylmalonicadj.

Brit.

/ˌmiːθʌɪlməˈlɒnɪk/, U.S.

/ˈˌmɛθəlməˈloʊnɪk/; see also methyl n. and malonic adj.

Origin: Formed within English, by compounding; modelled on a German lexical item. Etymons: methyl n., malonic adj.

Etymology: < methyl n. + malonic adj., after German Methylmalonsäure methylmalonic acid (1880 in Ann. der Chem. 204 202).

1. Chemistry and Biochemistry methylmalonic acid n. a dicarboxylic acid isomeric with succinic acid, (CH₃)CH(COOH)₂.

ΘΚΠ

the world > matter > chemistry > organic chemistry > organic acids > [noun] > dicarboxylic acids > miscellaneous others

suberic acid1796

oxalovinic acid1838

citraconic acid1840

melanic acid1840

citramalic acid1864

citratartaric acid1864

isophthalic acid1870

methylmalonic acid1889

norpinic acid1909

naphthalic acid1920

1889 Jrnl. Chem. Soc. 56 1097 Methylmalonic acid, C₄H₆O₄.

1922 J. J. Sudborough Bernthsen's Text-bk. Org. Chem. (new ed.) x. 241 Hence the names ethylene- and ethylidene-succinic acids, or more commonly succinic acid and methylmalonic acid.

1955 Nature 29 Oct. 823/1 Control experiments excluded the possibility that free methylmalonic acid is formed first and activated afterwards.

1964 Ann. N.Y. Acad. Sci. 112 915 Methylmalonic acid excretion and vitamin B₁₂ deficiency in the human.

1977 Jrnl. Dairy Sci. 60 1816 Methylmalonic acid was measured in cattle urine by decarboxylating it to propionate with sulfuric acid and heat and quantifying the propionate so formed by gas-liquid chromatography.

2000 Amer. Jrnl. Psychiatry 157 715 The depressed subjects..had a significantly higher serum methylmalonic acid level and a nonsignificantly lower serum vitamin B₁₂ level than the nondepressed subjects.

2. Medicine methylmalonic aciduria n. the presence of an abnormally large amount of methylmalonic acid in the urine, esp. as a manifestation of an inborn error of metabolism; an instance of this.

ΚΠ

1967 Arch. Dis. Childhood 42 492 (title) Methylmalonic aciduria. An inborn error of metabolism leading to chronic metabolic acidosis.

1981 Pediatrics 67 26 Screening neonates for methylmalonic aciduria is part of routine screening for metabolic disorders in Massachusetts.

1999 Jrnl. Amer. Animal Hosp. Assoc. 35 392 A methylmalonic aciduria was found on urinalysis.

3. Medicine methylmalonic acidaemia n. any of several inherited metabolic disorders characterized by the presence of an abnormally large quantity of methylmalonic acid in the blood and urine.

ΘΚΠ

the world > health and disease > ill health > a disease > disorders of internal organs > disorders of blood > [noun] > excess of other substances

hyperinosis1845

uricaemia1866

acetonaemia1874

hyperalbuminosis1876

chloraemia1890

acidaemia1891

hypercholesteraemia1894

hyperglycaemia1894

hyperlipaemia1894

hyperuricaemia1894

lymphocytosis1896

urataemia1897

acidosis1900

basophilia1905

mononucleosis1907

hypercapnia1908

thrombocytosis1909

thyrotoxicosis1911

monocytosis1914

hypercholesterolaemia1916

hyperparathyroidism1917

ketonaemia1917

lymphocytoma1920

hyperchloraemia1921

alkalaemia1922

hyperproteinaemia1922

reticulosis1922

hyperbilirubinaemia1923

hyperinsulinaemia1924

hypercalcaemia1925

hyperphosphataemia1926

reticulocytosis1926

hypernatraemia1932

hyperpotassaemia1932

thrombocythaemia1932

hypermagnesaemia1933

hyperglobulinaemia1936

granulocytosis1937

myeloblastosis1937

hypergammaglobulinaemia1947

hyperkalaemia1949

macroglobulinaemia1949

aldosteronism1954

Waldenström1961

mono1964

tyrosinaemia1965

methylmalonic acidaemia1969

1969 G. Morrow et al. in Proc. National Acad. Sci. U.S.A. 63 191 (title) Congenital methylmalonic acidemia: enzymatic evidence for two forms of the disease.

1982 Jrnl. Inherited & Metabolic Disorders 5 137 Congenital methylmalonic acidaemia was diagnosed in an 8-month-old girl who presented with severe metabolic acidosis, hypoglycaemia and hyperglycinaemia.

1998 Jrnl. Pediatrics 132 1043 A 13-year-old boy with non-B₁₂-responsive methylmalonic acidemia had chronic renal failure.

This is a new entry (OED Third Edition, December 2001; most recently modified version published online March 2022).

单词	methylmalonic
释义	methylmalonicadj. Brit. /ˌmiːθʌɪlməˈlɒnɪk/, U.S. /ˈˌmɛθəlməˈloʊnɪk/; see also methyl n. and malonic adj. Origin: Formed within English, by compounding; modelled on a German lexical item. Etymons: methyl n., malonic adj. Etymology: < methyl n. + malonic adj., after German Methylmalonsäure methylmalonic acid (1880 in Ann. der Chem. 204 202). 1. Chemistry and Biochemistry methylmalonic acid n. a dicarboxylic acid isomeric with succinic acid, (CH₃)CH(COOH)₂. ΘΚΠ the world > matter > chemistry > organic chemistry > organic acids > [noun] > dicarboxylic acids > miscellaneous others suberic acid1796 oxalovinic acid1838 citraconic acid1840 melanic acid1840 citramalic acid1864 citratartaric acid1864 isophthalic acid1870 methylmalonic acid1889 norpinic acid1909 naphthalic acid1920 1889 Jrnl. Chem. Soc. 56 1097 Methylmalonic acid, C₄H₆O₄. 1922 J. J. Sudborough Bernthsen's Text-bk. Org. Chem. (new ed.) x. 241 Hence the names ethylene- and ethylidene-succinic acids, or more commonly succinic acid and methylmalonic acid. 1955 Nature 29 Oct. 823/1 Control experiments excluded the possibility that free methylmalonic acid is formed first and activated afterwards. 1964 Ann. N.Y. Acad. Sci. 112 915 Methylmalonic acid excretion and vitamin B₁₂ deficiency in the human. 1977 Jrnl. Dairy Sci. 60 1816 Methylmalonic acid was measured in cattle urine by decarboxylating it to propionate with sulfuric acid and heat and quantifying the propionate so formed by gas-liquid chromatography. 2000 Amer. Jrnl. Psychiatry 157 715 The depressed subjects..had a significantly higher serum methylmalonic acid level and a nonsignificantly lower serum vitamin B₁₂ level than the nondepressed subjects. 2. Medicine methylmalonic aciduria n. the presence of an abnormally large amount of methylmalonic acid in the urine, esp. as a manifestation of an inborn error of metabolism; an instance of this. ΚΠ 1967 Arch. Dis. Childhood 42 492 (title) Methylmalonic aciduria. An inborn error of metabolism leading to chronic metabolic acidosis. 1981 Pediatrics 67 26 Screening neonates for methylmalonic aciduria is part of routine screening for metabolic disorders in Massachusetts. 1999 Jrnl. Amer. Animal Hosp. Assoc. 35 392 A methylmalonic aciduria was found on urinalysis. 3. Medicine methylmalonic acidaemia n. any of several inherited metabolic disorders characterized by the presence of an abnormally large quantity of methylmalonic acid in the blood and urine. ΘΚΠ the world > health and disease > ill health > a disease > disorders of internal organs > disorders of blood > [noun] > excess of other substances hyperinosis1845 uricaemia1866 acetonaemia1874 hyperalbuminosis1876 chloraemia1890 acidaemia1891 hypercholesteraemia1894 hyperglycaemia1894 hyperlipaemia1894 hyperuricaemia1894 lymphocytosis1896 urataemia1897 acidosis1900 basophilia1905 mononucleosis1907 hypercapnia1908 thrombocytosis1909 thyrotoxicosis1911 monocytosis1914 hypercholesterolaemia1916 hyperparathyroidism1917 ketonaemia1917 lymphocytoma1920 hyperchloraemia1921 alkalaemia1922 hyperproteinaemia1922 reticulosis1922 hyperbilirubinaemia1923 hyperinsulinaemia1924 hypercalcaemia1925 hyperphosphataemia1926 reticulocytosis1926 hypernatraemia1932 hyperpotassaemia1932 thrombocythaemia1932 hypermagnesaemia1933 hyperglobulinaemia1936 granulocytosis1937 myeloblastosis1937 hypergammaglobulinaemia1947 hyperkalaemia1949 macroglobulinaemia1949 aldosteronism1954 Waldenström1961 mono1964 tyrosinaemia1965 methylmalonic acidaemia1969 1969 G. Morrow et al. in Proc. National Acad. Sci. U.S.A. 63 191 (title) Congenital methylmalonic acidemia: enzymatic evidence for two forms of the disease. 1982 Jrnl. Inherited & Metabolic Disorders 5 137 Congenital methylmalonic acidaemia was diagnosed in an 8-month-old girl who presented with severe metabolic acidosis, hypoglycaemia and hyperglycinaemia. 1998 Jrnl. Pediatrics 132 1043 A 13-year-old boy with non-B₁₂-responsive methylmalonic acidemia had chronic renal failure. This is a new entry (OED Third Edition, December 2001; most recently modified version published online March 2022). < adj.1889
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