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单词 methysergide
释义

methysergiden.

Brit. /mɛθɪˈsəːdʒʌɪd/, U.S. /ˌmɛθɪˈsərdʒaɪd/
Origin: Formed within English, by compounding. Etymons: methyl n., lysergic adj., amide n.
Etymology: < meth- (in methyl n.: see note s.v. meth- comb. form) + -yserg- (in lysergic adj.) + -ide (in amide n.).
Pharmacology.
A lysergic acid derivative that acts as a selective serotonin receptor antagonist, and is sometimes used, usually in the form of its maleate, for the prevention of severe migraine and cluster headaches; 1-methyl- d-lysergic acid butanolamide, C21H28N3O2.
ΘΚΠ
the world > health and disease > healing > medicines or physic > medicines for specific purpose > preparations treating or preventing specific ailments > [noun] > for migraine
methysergide1962
sumatriptan1989
1962 Amer. Jrnl. Med. Sci. 243 152/1 Fifty-seven patients..were treated with antiserotonin agent, methysergide (UML-491).
1962 Daily Tel. 30 July 11/6 Methysergide (Deseril), is being tested as a preventive against chronic forms of migraine.
1968 J. H. Burn Lect. Notes Pharmacol. (ed. 9) 30 In some patients methysergide causes dizziness and nausea and produces aching in the legs.
1984 Regulatory Peptides 9 101 Changes in hormone secretion in response to serotonin were reversed by combined blockade of 5-HT1 and 5-HT2 receptors by methysergide.
1998 Cephalalgia 18 421 Methysergide can induce retroperitoneal fibrosis and pleural and heart valve fibrosis with an estimated incidence of 1 in 5,000 treated patients. Therefore, it should be reserved for severe cases in which other migraine preventive drugs are not effective.
This entry has been updated (OED Third Edition, December 2001; most recently modified version published online March 2022).
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n.1962
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