metoponn.

Brit.

/mᵻˈtəʊpɒn/, U.S.

/məˈtoʊˌpɑn/

Origin: Perhaps formed within English, by derivation. Etymons: methyl n., hydro- comb. form, morphine n., -one suffix.

Etymology: Perhaps < met- (in methyl n.) + -o (in hydro- comb. form) + -p- (in morphine n.) + -on (in -one suffix).

Pharmacology.

A narcotic analgesic derived from morphine, usually administered as the hydrochloride; dihydromethylmorphinone, C₁₈H₂₁NO₃.

ΚΠ

1947 Jrnl. Amer. Med. Assoc. 17 May 291/2 Chemically metopon differs from morphine in three particulars: one double bond of the phenanthrene nucleus has been reduced by hydrogenation, the alcoholic hydroxyl has been replaced by oxygen and..a methyl group has been attached to the phenanthrene nucleus.

1951 A. Grollman Pharmacol. & Therapeutics iv. 90 The introduction of an alkyl group in position 7, as in metopon, increases analgesic action while decreasing emetic, sedative and euphoric effects.

1970 F. N. Douglas Essent. Pharmacol. in Clin. Nursing viii. 118 Metopon Hydrochloride..is a morphine derivative.

1995 European Jrnl. Pharmacol. 294 201 These findings demonstrate metopon and its isomer bound with high affinity to the μ-opioid receptor and produced antinociception through this receptor.

This is a new entry (OED Third Edition, December 2001; most recently modified version published online March 2022).

单词	metopon
释义	metoponn. Brit. /mᵻˈtəʊpɒn/, U.S. /məˈtoʊˌpɑn/ Origin: Perhaps formed within English, by derivation. Etymons: methyl n., hydro- comb. form, morphine n., -one suffix. Etymology: Perhaps < met- (in methyl n.) + -o (in hydro- comb. form) + -p- (in morphine n.) + -on (in -one suffix). Pharmacology. A narcotic analgesic derived from morphine, usually administered as the hydrochloride; dihydromethylmorphinone, C₁₈H₂₁NO₃. ΚΠ 1947 Jrnl. Amer. Med. Assoc. 17 May 291/2 Chemically metopon differs from morphine in three particulars: one double bond of the phenanthrene nucleus has been reduced by hydrogenation, the alcoholic hydroxyl has been replaced by oxygen and..a methyl group has been attached to the phenanthrene nucleus. 1951 A. Grollman Pharmacol. & Therapeutics iv. 90 The introduction of an alkyl group in position 7, as in metopon, increases analgesic action while decreasing emetic, sedative and euphoric effects. 1970 F. N. Douglas Essent. Pharmacol. in Clin. Nursing viii. 118 Metopon Hydrochloride..is a morphine derivative. 1995 European Jrnl. Pharmacol. 294 201 These findings demonstrate metopon and its isomer bound with high affinity to the μ-opioid receptor and produced antinociception through this receptor. This is a new entry (OED Third Edition, December 2001; most recently modified version published online March 2022). < n.1947
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