midzonaladj.
/mɪdˈzəʊnl/, U.S. /ˌmɪdˈzoʊn(ə)l/ 1. Palaeontology. Belonging or relating to a middle stratigraphical layer (cf. zone n. 7).
ΚΠ
1914 W. K. Spencer in Philos. Trans. (Royal Soc.) B. 204 101 A ‘mid-zonal’ period, up to and including the lower third of the zone of Actinocamax quadratus.
2. Pathology and Histology. Of, relating to, or designating the part of a liver lobule that lies between its periportal and pericentral areas.
ΚΠ
1929 W. W. C. Topley & G. S. Wilson Princ. Bacteriol. & Immunity II. lxxxii. 1250 The most constant feature..is the pale, mottled liver, which microscopically shows fatty degeneration and mid-zonal necrosis.
1976 G. M. Edington & H. M. Gilles Pathol. in Tropics (ed. 2) iv. 222 The usual lesion [in yellow fever] is ‘midzonal’ necrosis of the parenchymal cells of the liver... Frequently, however, almost the complete lobule may be involved.
1988 J. C. Bell et al. Zoonoses 220 Microglobular fatty degeneration of liver cells occurs with disruption of the hepatic lobule and necrosis of midzonal liver cells.
1997 Jrnl. Hepatol. 26 343 Biliary epithelial cells (ductular oval cells) migrate into the periportal and midzonal parenchyma when hepatocyte regeneration after injury is significantly impeded.
This is a new entry (OED Third Edition, March 2002; most recently modified version published online March 2022).
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adj.1914