minichromosomen.

1975 J. D. Griffith in Science 28 Mar. 1202/2 The structure, nuclear location, and stoichiometry of histones in this SV40 complex suggest that it is a very small chromosome, here termed a minichromosome.

1983 B. Lewin Genes xxix. 464 (caption) The supercoils of the minichromosome can be relaxed to generate a circular structure, whose loss of histones then generates supercoils in the free DNA.

1994 Proc. National Acad. Sci. U.S.A. 91 7051/2 BPV [= bovine papillomavirus] DNA exists as a minichromosome in the living cell.

2001 Jrnl. Molec. Biol. 307 183 The replicative intermediate of hepatitis B virus, the covalently closed, circular DNA, is organized into minichromosomes in the nucleus of the infected cell by histone and non-histone proteins.

1976 Nature 22 July 256/1 The ends of the gene-sized minichromosomes of hypotrich ciliate macronuclei are palindromic.

1978 Nature 12 Oct. 561/2 We have used the same technique to isolate minichromosomes from the total chromosomal DNA of E. coli K12 and have found that two different chromosomal EcoRI fragments can function as autonomously replicating plasmids.

1988 Mouse News Let. Nov. 126 This resolution overlaps the size of fragments that can now be cloned using yeast minichromosomes.

1992 New Scientist 15 Feb. 15/2 Rather than use a virus, Williamson wants to develop ‘minichromosomes’—artificial chromosomes containing the replacement gene or genes, plus the machinery of normal chromosomes that allows genes to be organised when the cell divides.

1995 Chromosoma 103 676/1 Some of these sequences appear to be present in substantial quantities in the smallest minichromosome of Drosophila.