misfoldv.

Brit.

/ˌmɪsˈfəʊld/, U.S.

/ˌmɪsˈfoʊld/

Origin: Formed within English, by derivation. Etymons: mis- prefix¹, fold v.¹

Etymology: < mis- prefix¹ + fold v.¹ Compare misfolded adj., misfolding n.

Molecular Biology.

intransitive. Of a protein or nucleic acid molecule: to fold into an incorrect tertiary structure. Also (occasionally) transitive (in passive).

ΚΠ

1971 Proc. National Acad. Sci. U.S.A. 68 2939/1 The enzyme..had undergone association at alkaline pH to an immature form, which, in the absence of the directive influence of ATP, was ‘misfolded’.

1989 EMBO Jrnl. 8 3517 Efficient translocation of proteins across biological membranes is thought to be supported by cytoplasmic factors that protect presecretory molecules from being misfolded.

1993 Jrnl. Biol. Chem. 268 13777 It is proposed that the subunits are no longer able to kinetically equilibrate with folding intermediates that misfold or aggregate.

1994 EMBO Jrnl. 13 2913 Non-specific RNA binding proteins..may have a biological role as RNA chaperones that prevent misfolding of RNAs and resolve RNAs that have misfolded.

2000 Times 11 May ii. 8/5 This prompts neighbouring prion molecules to misfold, and causes abnormal protein to build up quickly.

This is a new entry (OED Third Edition, June 2002; most recently modified version published online March 2022).

单词	misfold
释义	misfoldv. Brit. /ˌmɪsˈfəʊld/, U.S. /ˌmɪsˈfoʊld/ Origin: Formed within English, by derivation. Etymons: mis- prefix¹, fold v.¹ Etymology: < mis- prefix¹ + fold v.¹ Compare misfolded adj., misfolding n. Molecular Biology. intransitive. Of a protein or nucleic acid molecule: to fold into an incorrect tertiary structure. Also (occasionally) transitive (in passive). ΚΠ 1971 Proc. National Acad. Sci. U.S.A. 68 2939/1 The enzyme..had undergone association at alkaline pH to an immature form, which, in the absence of the directive influence of ATP, was ‘misfolded’. 1989 EMBO Jrnl. 8 3517 Efficient translocation of proteins across biological membranes is thought to be supported by cytoplasmic factors that protect presecretory molecules from being misfolded. 1993 Jrnl. Biol. Chem. 268 13777 It is proposed that the subunits are no longer able to kinetically equilibrate with folding intermediates that misfold or aggregate. 1994 EMBO Jrnl. 13 2913 Non-specific RNA binding proteins..may have a biological role as RNA chaperones that prevent misfolding of RNAs and resolve RNAs that have misfolded. 2000 Times 11 May ii. 8/5 This prompts neighbouring prion molecules to misfold, and causes abnormal protein to build up quickly. This is a new entry (OED Third Edition, June 2002; most recently modified version published online March 2022). < v.1971
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