misfoldedadj.
/ˌmɪsˈfəʊldɪd/, U.S. /ˌmɪsˈfoʊldəd/ Molecular Biology.
Of a protein or nucleic acid molecule: that has undergone misfolding.
ΚΠ
1971 Proc. National Acad. Sci. U.S.A. 68 1240/1 The irreversible transition to the misfolded state.
1984 Jrnl. Molecular Biol. 177 787 Certain features that characterize native proteins are made evident by their absence in misfolded models.
1994 EMBO Jrnl. 13 2913 NC protein is shown to resolve a misfolded ribozyme-RNA complex that is otherwise long lived.
1997 Ess. in Biochem. 32 17 The accumulation of misfolded proteins has also become a central issue to diseases of protein folding, including sickle cell haemoglobin, cystic fibrosis and prion diseases.
2000 RNA 6 790 The RNA is easily trapped in metastable misfolded structures.
This is a new entry (OED Third Edition, June 2002; most recently modified version published online March 2022).
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adj.1971