misfoldingn.

Brit.

/ˌmɪsˈfəʊldɪŋ/, U.S.

/ˌmɪsˈfoʊldɪŋ/

Origin: Formed within English, by derivation. Etymons: mis- prefix¹, folding n.¹

Etymology: < mis- prefix¹ + folding n.¹, after misfold v. Compare misfolded adj.

Molecular Biology.

Incorrect folding in the formation of the tertiary structure of a protein or nucleic acid molecule; an instance of this.

ΚΠ

1971 Proc. National Acad. Sci. U.S.A. 68 2940/1 Besides preconditioning, the enzyme can undergo another fate, namely, ‘misfolding’ to an inactive species.

1984 FEBS Lett. 177 179 These data suggest that the abnormal alpha 1-antitrypsin is blocked in the secretory pathway prior to its entrance into the Golgi, and that this blockage is not due to a gross misfolding of the polypeptide.

1990 Jrnl. Cell Biol. 110 1705 We propose that the formation of intermolecular disulfide bonds is not an intermediate step in the maturation of the envelope glycoprotein, but rather a result of misfolding of the gp160 precursor which prevents it from being properly processed.

1998 Chicago Tribune 11 Jan. ii. 3/2 It [sc. Alzheimer's] is almost certainly caused by the misfolding of key proteins in the brain.

This is a new entry (OED Third Edition, June 2002; most recently modified version published online March 2022).

单词	misfolding
释义	misfoldingn. Brit. /ˌmɪsˈfəʊldɪŋ/, U.S. /ˌmɪsˈfoʊldɪŋ/ Origin: Formed within English, by derivation. Etymons: mis- prefix¹, folding n.¹ Etymology: < mis- prefix¹ + folding n.¹, after misfold v. Compare misfolded adj. Molecular Biology. Incorrect folding in the formation of the tertiary structure of a protein or nucleic acid molecule; an instance of this. ΚΠ 1971 Proc. National Acad. Sci. U.S.A. 68 2940/1 Besides preconditioning, the enzyme can undergo another fate, namely, ‘misfolding’ to an inactive species. 1984 FEBS Lett. 177 179 These data suggest that the abnormal alpha 1-antitrypsin is blocked in the secretory pathway prior to its entrance into the Golgi, and that this blockage is not due to a gross misfolding of the polypeptide. 1990 Jrnl. Cell Biol. 110 1705 We propose that the formation of intermolecular disulfide bonds is not an intermediate step in the maturation of the envelope glycoprotein, but rather a result of misfolding of the gp160 precursor which prevents it from being properly processed. 1998 Chicago Tribune 11 Jan. ii. 3/2 It [sc. Alzheimer's] is almost certainly caused by the misfolding of key proteins in the brain. This is a new entry (OED Third Edition, June 2002; most recently modified version published online March 2022). < n.1971
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