misincorporationn.
/ˌmɪsᵻnˌkɔːpəˈreɪʃn/, /ˌmɪsɪŋˌkɔːpəˈreɪʃn/, U.S. /ˈˌmɪsᵻnˌkɔrpəˈreɪʃ(ə)n/ Molecular Biology.
The incorporation into a protein, nucleic acid, or other biological polymer of a residue that differs from the one normally found at a given position; an instance of this.
ΚΠ
1965 Proc. National Acad. Sci. U.S.A. 54 1082 There is a basal level of misincorporation of both amino acids.
1978 Nature 13 Apr. 582/3 Since the frequent random substitution of uracil for thymine during T4 DNA synthesis seems to have no serious consequences for the subsequent phage replication, the occasional misincorporation of uracil may have only minor effects on replication and transcription.
1986 Proc. National Acad. Sci. U.S.A. 83 28/1 The frequent misincorporations of dGTP would be expected to produce transitions in vivo.
1990 Nucleic Acids Res. 18 324/2 The inherent nucleotide misincorporation rate for the PCR amplification and cloning procedure is about 0.25%.
This is a new entry (OED Third Edition, June 2002; most recently modified version published online March 2022).
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n.1965