monoaminen.

Brit.

/ˌmɒnəʊˈeɪmiːn/, U.S.

/ˌmɑnoʊˈeɪˌmin/,

/ˌmɑnoʊəˈmin/

Forms: 1800s– monamine, 1900s– monoamine.

Origin: Formed within English, by compounding. Etymons: mono- comb. form, amine n.

Etymology: < mono- comb. form + amine n. Compare diamine n., polyamine n. at poly- comb. form 2.

Chemistry and Biochemistry.

A compound having a single (primary, secondary, or tertiary) amine group in the molecule; spec. one which is a neurotransmitter (e.g. serotonin or noradrenalin).

ΘΚΠ

the world > matter > chemistry > organic chemistry > amines > [noun] > monoamine

monoamine1859

1859 A. W. Hofmann in Proc. Royal Soc. 9 293 Contributions towards the History of the Monamines.

1878 C. T. Kingzett Animal Chem. 35 The amines..may be grouped into 3 classes, namely monamines, diamines, and triamines.

1906 H. J. H. Fenton Notes Qualitative Anal. (new ed.) 111 With a concentrated solution of sodium nitroprusside and a few drops of a solution of an aliphatic monamine.., a magenta colour is obtained.

1922 J. J. Sudborough Bernthsen's Text-bk. Org. Chem. (new ed.) lv. 840 The formation of aposafranines, safranines, and indulines from aminoazo compounds and monoamine salts probably proceeds in several stages.

1965 J. Pollitt Depression & its Treatm. iv. 53 Monoamines are neurohormones regarded as essential for normal activity of the brain.

2000 Independent on Sunday 9 Jan. (Review Suppl.) 14/3 The first generation of antidepressant drugs were not magic bullets: they influenced more than one monoamine system.

Compounds

monoamine oxidase n. an enzyme which catalyses the oxidation (and hence the inactivation) of monoamine neurotransmitters; abbreviated MAO.

ΚΠ

1943 J. B. Sumner & G. F. Somers Chem. & Methods of Enzymes xv. 269 It is probable that all of these enzymes are one and the same... The most suitable name for the enzyme would be ‘monamine oxidase’.

1968 Brain 91 516 These nuclei with high monamine oxidase contents are related to pathways which mediate olfacto-visceral and olfacto-somatic correlations.

1996 Guardian 22 Feb. i. 6/5 The brains of smokers really are different: they contain 40 per cent less of an enigmatic enzyme called monoamine oxidase B.

monoamine oxidase inhibitor n. any of a class of drugs which inhibit the functioning of monoamine oxidase (so allowing accumulation of serotonin and noradrenalin in the brain), some of which are used as antidepressants; abbreviated MAOI.

ΘΚΠ

the world > health and disease > healing > medicines or physic > medicines for specific purpose > medicine for mental conditions > [noun] > antidepressant > specific drugs

Marsilid1952

iproniazid1953

levallorphan1953

imipramine1958

Tofranil1958

isocarboxazid1959

Marplan1959

Nardil1959

nialamide1959

Niamid1959

phenelzine1959

tranylcypromine1959

Parnate1960

amitriptyline1961

monoamine oxidase inhibitor1962

nortriptyline1962

protriptyline1963

MAOI1965

maprotiline1970

mianserin1970

amoxapine1971

fluoxetine1975

paroxetine1977

Prozac1985

Seroxat1985

1962 Lancet 29 Dec. 1343/1 There is a strong impression that iproniazid is clinically more effective in relieving depression than other monoamine-oxidase inhibitors.

1967 Brit. Jrnl. Psychiatry 113 363/2 The hypertensive crisis..could have been anticipitated before the introduction of monamine oxidase inhibitors into clinical medicine.

1993 Dog World June 30/2 Since Amitraz is a monoamine oxidase inhibitor, it damages the nervous system of the tick, effectively paralyzing attached ticks so that they fully detach and fall off your pet.

This entry has been updated (OED Third Edition, December 2002; most recently modified version published online March 2022).

单词	monoamine
释义	monoaminen. Brit. /ˌmɒnəʊˈeɪmiːn/, U.S. /ˌmɑnoʊˈeɪˌmin/, /ˌmɑnoʊəˈmin/ Forms: 1800s– monamine, 1900s– monoamine. Origin: Formed within English, by compounding. Etymons: mono- comb. form, amine n. Etymology: < mono- comb. form + amine n. Compare diamine n., polyamine n. at poly- comb. form 2. Chemistry and Biochemistry. A compound having a single (primary, secondary, or tertiary) amine group in the molecule; spec. one which is a neurotransmitter (e.g. serotonin or noradrenalin). ΘΚΠ the world > matter > chemistry > organic chemistry > amines > [noun] > monoamine monoamine1859 1859 A. W. Hofmann in Proc. Royal Soc. 9 293 Contributions towards the History of the Monamines. 1878 C. T. Kingzett Animal Chem. 35 The amines..may be grouped into 3 classes, namely monamines, diamines, and triamines. 1906 H. J. H. Fenton Notes Qualitative Anal. (new ed.) 111 With a concentrated solution of sodium nitroprusside and a few drops of a solution of an aliphatic monamine.., a magenta colour is obtained. 1922 J. J. Sudborough Bernthsen's Text-bk. Org. Chem. (new ed.) lv. 840 The formation of aposafranines, safranines, and indulines from aminoazo compounds and monoamine salts probably proceeds in several stages. 1965 J. Pollitt Depression & its Treatm. iv. 53 Monoamines are neurohormones regarded as essential for normal activity of the brain. 2000 Independent on Sunday 9 Jan. (Review Suppl.) 14/3 The first generation of antidepressant drugs were not magic bullets: they influenced more than one monoamine system. Compounds monoamine oxidase n. an enzyme which catalyses the oxidation (and hence the inactivation) of monoamine neurotransmitters; abbreviated MAO. ΚΠ 1943 J. B. Sumner & G. F. Somers Chem. & Methods of Enzymes xv. 269 It is probable that all of these enzymes are one and the same... The most suitable name for the enzyme would be ‘monamine oxidase’. 1968 Brain 91 516 These nuclei with high monamine oxidase contents are related to pathways which mediate olfacto-visceral and olfacto-somatic correlations. 1996 Guardian 22 Feb. i. 6/5 The brains of smokers really are different: they contain 40 per cent less of an enigmatic enzyme called monoamine oxidase B. monoamine oxidase inhibitor n. any of a class of drugs which inhibit the functioning of monoamine oxidase (so allowing accumulation of serotonin and noradrenalin in the brain), some of which are used as antidepressants; abbreviated MAOI. ΘΚΠ the world > health and disease > healing > medicines or physic > medicines for specific purpose > medicine for mental conditions > [noun] > antidepressant > specific drugs Marsilid1952 iproniazid1953 levallorphan1953 imipramine1958 Tofranil1958 isocarboxazid1959 Marplan1959 Nardil1959 nialamide1959 Niamid1959 phenelzine1959 tranylcypromine1959 Parnate1960 amitriptyline1961 monoamine oxidase inhibitor1962 nortriptyline1962 protriptyline1963 MAOI1965 maprotiline1970 mianserin1970 amoxapine1971 fluoxetine1975 paroxetine1977 Prozac1985 Seroxat1985 1962 Lancet 29 Dec. 1343/1 There is a strong impression that iproniazid is clinically more effective in relieving depression than other monoamine-oxidase inhibitors. 1967 Brit. Jrnl. Psychiatry 113 363/2 The hypertensive crisis..could have been anticipitated before the introduction of monamine oxidase inhibitors into clinical medicine. 1993 Dog World June 30/2 Since Amitraz is a monoamine oxidase inhibitor, it damages the nervous system of the tick, effectively paralyzing attached ticks so that they fully detach and fall off your pet. This entry has been updated (OED Third Edition, December 2002; most recently modified version published online March 2022). < n.1859
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