multicentricadj.
/ˌmʌltɪˈsɛntrɪk/, U.S. /ˌməltiˈsɛntrɪk/; see also multi- comb. form. 1.
a. Designating, exhibiting, or relating to origin from, or involvement of, several sites in the body or an organ.
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the world > space > relative position > central condition or position > [adjective] > having three or many centres
tricentral1642
multicentric1911
1911 Proc. Royal Soc. 1910–11 B. 83 534 Changes might be found which could account for the frequency and the multicentric origin of the tumours.
1958 Science 26 Sept. 698/1 Cancer..is usually multicentric in its earliest visible stages.
1972 Year Bk. Dermatol. 185 The present study examined the ultrastructural characteristics of multicentric reticulohistiocytosis.
2000 Mil. Med. 165 670 The incidence of multicentric renal malignancy is low.
b. Biology. Of a chromosome: having more than one centromere; spec. having more than two centromeres.
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the world > life > biology > biological processes > genetic activity > genetic components > [adjective] > chromosome > centromere
acentric1899
telomitic1917
centric1937
paracentric1938
pericentric1938
metacentric1939
telocentric1939
centromeric1941
multicentric1941
polycentric1943
acrocentric1945
subtelocentric1954
submetacentric1957
subacrocentric1960
1941 Cold Spring Harbor Symp. Quantitative Biol. 9 153 Di- and multicentric chromosomes.
1970 Proc. National Acad. Sci. U.S.A. 66 921 Multicentric chromosomes were scored in accordance with the number of centromeres.
1993 Cancer Genetics & Cytogenetics 70 31 Neoplastic cells may carry inactive centromeres on some multicentric, yet stable, chromosomes.
2000 Human Genetics 107 376 This finding complements previous studies on multicentric chromosomes demonstrating specific association of structural and motor-related centromere proteins with active centromeres.
c. gen. Relating to or having many centres or foci.
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1959 Jrnl. Econ. Hist. 19 492 A multicentric economy is an economy in which a society's exchangeable goods fall into two or more mutually exclusive spheres.
1975 M. Lambert Malory iii. 166 Malorian tragedy is multicentric: we understand all the parts, but not the whole.
1989 Third Text Summer 68 This fusion has created a kind of multicentric perspective in Latin American culture that allows for narrative, for spiral thinking.
1997 Jrnl. Black Stud. 27 314 Unique historical and cultural experiences..are deemed to have helped to shape what amounts to an African perspective in the multicentric world.
2. Medicine. Of a study or trial: = multicentre adj. 2.
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1968 Acta Neurologica et Psychiatrica Belgica 68 875 (title) A multicentric clinical evaluation of pimozide: preliminary report.
1988 Contraception 37 493 Multicentric clinical trials..confirm a reliable contraceptive efficacy.
1998 Radiotherapy & Oncol. 47 37 This fact raises the question of the reproducibility when pooling patients in multicentric trials.
This entry has been updated (OED Third Edition, March 2003; most recently modified version published online March 2022).
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adj.1911