naloxonen.
/nəˈlɒksəʊn/, U.S. /nəˈlɑkˌsoʊn/ Pharmacology.
A synthetic opioid antagonist which resembles nalorphine in its chemical structure and is given intravenously (usually in the form of its hydrochloride) in the treatment of opioid overdosage; (−)-(5R,14S)-9a-allyl-4,5-epoxy-3,14-dihydroxymorphinan-6-one, C19H21NO4.
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Nalline1952
nalorphine1953
naloxone1964
naltrexone1973
1964 Amer. Jrnl. Med. Sci. 247 412 The n-allyl derivative of oxymorphone (Numorphan) has recently been synthesized and found to be a potent narcotic antagonist... It has also been suggested that this preparation (Naloxone), differs from other narcotic antagonists in that its administration simultaneously with a narcotic results in antagonism of the respiratory depression but not of the analgesia induced by the narcotic.
1978 D. Francis Trial Run xi. 153 As far as I could make out, it said 0.4 mg naloxone, which was spectacularly unhelpful, as I'd never heard of the stuff.
1989 Adverse Drug Reactions & Acute Poisoning Rev. 8 103 Naloxone has been demonstrated to antagonize GABA in both human and rat central nervous systems.
1999 Chem. in Brit. Mar. 22/3 Naloxone and Naltrexone are not ‘substitutes’, rather they are used once detoxification has been completed with the purpose of preventing relapse.
This entry has been updated (OED Third Edition, June 2003; most recently modified version published online March 2022).
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n.1964