naltrexonen.

Brit.

/nalˈtrɛksəʊn/, U.S.

/nælˈtrɛkˌsoʊn/

Origin: A variant or alteration of another lexical item. Etymons: naloxone n., English -tre-.

Etymology: < naloxone n., with insertion of -tre- (perhaps an arbitrary element, or perhaps < tri- comb. form, with reference to the distinctive cyclopropyl group).

Pharmacology.

A synthetic morphinan derivative that is a potent opioid antagonist, administered orally (as the hydrochloride) to prevent relapse in heroin addicts after detoxification; (5R)-9a-cyclopropylmethyl-3,14-dihydroxy-4,5-epoxymorphinan-6-one, C₂₀H₂₃NO₄.

ΘΚΠ

the world > health and disease > healing > medicines or physic > medicines for specific purpose > antidote > [noun] > narcotic antagonists

Nalline1952

nalorphine1953

naloxone1964

naltrexone1973

1973 Arch. Gen. Psychiatry 28 785/2 Naltrexone is approximately 17 times more potent than nalorphine in precipitating abstinence in patients dependent on 60 mg of morphine a day.

1978 Nature 9 Mar. 167/1 This treatment is designed to diminish the efficacy of any self-administered opiate by ‘blockading’ the receptors with substances such as naloxone or naltrexone.

1988 New Scientist 9 June 83/3 A similar bait has been advocated in order to ‘persuade’ heroin addicts to submit to a course of naltrexone, or to encourage criminal alcoholics to take the very nasty Antabuse.

1998 R. Stone Damascus Gate iii. 28 I'm not about to do that naltrexone treatment again.

This entry has been updated (OED Third Edition, June 2003; most recently modified version published online March 2022).

单词	naltrexone
释义	naltrexonen. Brit. /nalˈtrɛksəʊn/, U.S. /nælˈtrɛkˌsoʊn/ Origin: A variant or alteration of another lexical item. Etymons: naloxone n., English -tre-. Etymology: < naloxone n., with insertion of -tre- (perhaps an arbitrary element, or perhaps < tri- comb. form, with reference to the distinctive cyclopropyl group). Pharmacology. A synthetic morphinan derivative that is a potent opioid antagonist, administered orally (as the hydrochloride) to prevent relapse in heroin addicts after detoxification; (5R)-9a-cyclopropylmethyl-3,14-dihydroxy-4,5-epoxymorphinan-6-one, C₂₀H₂₃NO₄. ΘΚΠ the world > health and disease > healing > medicines or physic > medicines for specific purpose > antidote > [noun] > narcotic antagonists Nalline1952 nalorphine1953 naloxone1964 naltrexone1973 1973 Arch. Gen. Psychiatry 28 785/2 Naltrexone is approximately 17 times more potent than nalorphine in precipitating abstinence in patients dependent on 60 mg of morphine a day. 1978 Nature 9 Mar. 167/1 This treatment is designed to diminish the efficacy of any self-administered opiate by ‘blockading’ the receptors with substances such as naloxone or naltrexone. 1988 New Scientist 9 June 83/3 A similar bait has been advocated in order to ‘persuade’ heroin addicts to submit to a course of naltrexone, or to encourage criminal alcoholics to take the very nasty Antabuse. 1998 R. Stone Damascus Gate iii. 28 I'm not about to do that naltrexone treatment again. This entry has been updated (OED Third Edition, June 2003; most recently modified version published online March 2022). < n.1973
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