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1986 K. E. Drexler Engines of Creation i. 5 The engineers of the new technology will build both nanocircuits and nanomachines.

1988 Sci. Amer. Jan. 88/1 There are already aqueous nanomachines (of a kind) in nature. Consider the well-known T4 bacteriophage, which replicates itself by invading the body of a bacterial host.

1998 Interzone July 18/1 Soon, at the top of the crystal column, a billion nanomachines were swarming and polymerizing surplus atoms into carbon-chains with pyridazine rings as switches.