neurotensinn.

Brit.

/ˌnjʊərə(ʊ)ˈtɛnsᵻn/, U.S.

/ˌn(j)ʊroʊˈtɛns(ə)n/

Origin: Formed within English, by compounding. Etymons: neuro- comb. form, angiotensin n., hypertensin n.

Etymology: < neuro- comb. form + -tensin (in angiotensin n., hypertensin n.).

Physiology.

A neuropeptide found in the mammalian brain and gastrointestinal tract, initially identified by vasodilatory activity but later recognized to have a wide variety of physiological effects.

ΚΠ

1973 R. Carraway & S. E. Leeman in Jrnl. Biol. Chem. 248 6854/1 The presence of a different peptide was detected that produces a visible vasodilation in the exposed cutaneous regions of anesthetized rats... This report presents a method for obtaining the peptide, which we have named neurotensin.

1976 Nature 12 Aug. 607/2 Neurotensin is a tridecapeptide (pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu-COOH) isolated from bovine hypothalami.

1989 Jrnl. Psychopharmacol. 3 100 High densities of neurotensin receptors are found in the substantia nigra pars compacta and ventral tegmental area.

1998 Proc. National Acad. Sci. U.S.A. 95 11462/1 Typical antipsychotic drugs, such as haloperidol and chlorpromazine, increase synthesis of the neuropeptide neurotensin (NT) in both the striatum and the nucleus accumbens.

This is a new entry (OED Third Edition, September 2003; most recently modified version published online March 2022).

单词	neurotensin
释义	neurotensinn. Brit. /ˌnjʊərə(ʊ)ˈtɛnsᵻn/, U.S. /ˌn(j)ʊroʊˈtɛns(ə)n/ Origin: Formed within English, by compounding. Etymons: neuro- comb. form, angiotensin n., hypertensin n. Etymology: < neuro- comb. form + -tensin (in angiotensin n., hypertensin n.). Physiology. A neuropeptide found in the mammalian brain and gastrointestinal tract, initially identified by vasodilatory activity but later recognized to have a wide variety of physiological effects. ΚΠ 1973 R. Carraway & S. E. Leeman in Jrnl. Biol. Chem. 248 6854/1 The presence of a different peptide was detected that produces a visible vasodilation in the exposed cutaneous regions of anesthetized rats... This report presents a method for obtaining the peptide, which we have named neurotensin. 1976 Nature 12 Aug. 607/2 Neurotensin is a tridecapeptide (pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu-COOH) isolated from bovine hypothalami. 1989 Jrnl. Psychopharmacol. 3 100 High densities of neurotensin receptors are found in the substantia nigra pars compacta and ventral tegmental area. 1998 Proc. National Acad. Sci. U.S.A. 95 11462/1 Typical antipsychotic drugs, such as haloperidol and chlorpromazine, increase synthesis of the neuropeptide neurotensin (NT) in both the striatum and the nucleus accumbens. This is a new entry (OED Third Edition, September 2003; most recently modified version published online March 2022). < n.1973
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