neomycinn.

1949 S. A. Waksman & H. A. Lechevalier in Science 25 Mar. 305/2 In search for new compounds, particular attention was paid to those that would be effective against streptomycin-resistant bacteria, notably against the streptomycin-resistant strains of M[ycobacterium] tuberculosis. The discovery of such an agent, designated as neomycin, is reported here.

1949 R. L. Peck et al. in Jrnl. Amer. Chem. Soc. 71 2590/2 Evidence has been obtained that the neomycin activity is due to more than one chemical entity; hence one may define it as a ‘neomycin-complex’. The substance isolated as described herein, has been designated neomycin A.

1960 M. E. Florey Clin. Appl. Antibiotics iv. v. 140 Neomycin..was expected to replace streptomycin since it was much less liable to induce resistance in pathogenic organisms.

1964 Proc. National Acad. Sci. U.S.A. 51 885 Kanamycin and neomycins B and C are aminoglycoside antibiotics structurally related to streptomycin and appear to have a similar mechanism of action.

1974 M. C. Gerald Pharmacol. iii. 45 The antibiotic neomycin is used to sterilize the gastrointestinal tract prior to abdominal surgery.

1988 Q. N. Myrvik & R. S. Weiser Fund. Med. Bacteriol. & Mycol. (ed. 2) vi. 97 Neomycin is too toxic to be used systemically and is restricted to topical use.

1998 Jrnl. Pharmacol. & Biomed. Anal. 17 757 The activity of neomycin C relative to neomycin B was found to be 62% by diffusion..and 56% by turbidimetry.

2001 N. Jones Rough Guide Trav. Health i. 23 Avoid this vaccine if..you're allergic to neomycin, polymyxin or egg protein.