neostigminen.

Brit.

/ˌniːə(ʊ)ˈstɪɡmiːn/, U.S.

/ˌnioʊˈstɪɡˌmin/

Origin: Formed within English, by compounding. Etymons: neo- comb. form, physostigmine n.

Etymology: < neo- comb. form + -stigmine (in physostigmine n.).

Pharmacology.

An aromatic quaternary ammonium salt, the bromide or methylsulphate of the ion (CH₃)₂N·CO·OC₆H₄N⁺(CH₃)₃, which inhibits cholinesterase activity and is chiefly used to treat myasthenia gravis and paralytic ileus and to reverse the effects of some muscle relaxants.

ΘΚΠ

the world > health and disease > healing > medicines or physic > medicines for specific purpose > preparations treating or preventing specific ailments > [noun] > for myasthenia

Prostigmine1931

neostigmine1943

pyridostigmine1953

1943 Proc. Soc. Exper. Biol. & Med. 54 254/1 Oral administration of 0·2 mg/kg of neostigmine bromide to mice reduces mortality in severe anoxia but larger doses are not prophylactic.

1951 A. Grollman Pharmacol. & Therapeutics xiii. 253 Neostigmine, like physostigmine, exerts its action by inactivating cholinesterase.

1973 Exper. Eye Res. 15 35 The increase in blood flow in the ciliary processes may be due to a direct effect on the muscarinic receptor of neostigmine, which is a quaternary compound, but it may also be due to an ability of neostigmine to release acetylcholine from the nerve terminals besides protecting it.

1989 Jrnl. Autoimmunity 2 901 Upon injection of 5μg neostigmine..the ‘drooping’ of the lip decreased markedly for about 2 h.

2001 Canad. Jrnl. Anesthesia 48 529 Reversal of neuromuscular blockade was achieved with 1.0 mg neostigmine and 0.2 mg atropine iv.

This entry has been updated (OED Third Edition, September 2003; most recently modified version published online March 2022).

单词	neostigmine
释义	neostigminen. Brit. /ˌniːə(ʊ)ˈstɪɡmiːn/, U.S. /ˌnioʊˈstɪɡˌmin/ Origin: Formed within English, by compounding. Etymons: neo- comb. form, physostigmine n. Etymology: < neo- comb. form + -stigmine (in physostigmine n.). Pharmacology. An aromatic quaternary ammonium salt, the bromide or methylsulphate of the ion (CH₃)₂N·CO·OC₆H₄N⁺(CH₃)₃, which inhibits cholinesterase activity and is chiefly used to treat myasthenia gravis and paralytic ileus and to reverse the effects of some muscle relaxants. ΘΚΠ the world > health and disease > healing > medicines or physic > medicines for specific purpose > preparations treating or preventing specific ailments > [noun] > for myasthenia Prostigmine1931 neostigmine1943 pyridostigmine1953 1943 Proc. Soc. Exper. Biol. & Med. 54 254/1 Oral administration of 0·2 mg/kg of neostigmine bromide to mice reduces mortality in severe anoxia but larger doses are not prophylactic. 1951 A. Grollman Pharmacol. & Therapeutics xiii. 253 Neostigmine, like physostigmine, exerts its action by inactivating cholinesterase. 1973 Exper. Eye Res. 15 35 The increase in blood flow in the ciliary processes may be due to a direct effect on the muscarinic receptor of neostigmine, which is a quaternary compound, but it may also be due to an ability of neostigmine to release acetylcholine from the nerve terminals besides protecting it. 1989 Jrnl. Autoimmunity 2 901 Upon injection of 5μg neostigmine..the ‘drooping’ of the lip decreased markedly for about 2 h. 2001 Canad. Jrnl. Anesthesia 48 529 Reversal of neuromuscular blockade was achieved with 1.0 mg neostigmine and 0.2 mg atropine iv. This entry has been updated (OED Third Edition, September 2003; most recently modified version published online March 2022). < n.1943
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