non-nucleosideadj.n.
/nɒnˈnjuːklɪə(ʊ)ˌsʌɪd/, U.S. /nɑ(n)ˈn(j)ukliəˌsaɪd/ Biochemistry and Pharmacology.
A. adj.
That is not a nucleoside; spec. designating drugs that inhibit retroviral reverse transcriptase but are not nucleoside analogues, used in the treatment of HIV infection.
ΚΠ
1987 Molecular & Cellular Biochem. 77 187 The synthetic nucleoside, ribavirin..and mycophenolic acid, a non-nucleoside inhibitor of inosinate (IMP) dehydrogenase, are effective inducers of terminal differentiation of Friend virus transformed murine erythroleukemia cells.
1990 Science 28 Sept. 1542/1 A number of new types of non-nucleoside compounds have recently been reported to be active against HIV in vitro.
1996 AIDS 10 635 Nevirapine is a non-nucleoside reverse transcriptase inhibitor of HIV-1 which exhibits synergy in vitro with zidovudine.
2002 Washington Post 26 Feb. (Home ed.) a2/5 Researchers here also heard about the early success of a drug specifically designed to avoid resistance problems encountered by nevirapine and efavirenz, the two existing members in its class of drugs, known as non-nucleoside reverse transcriptase inhibitors.
B. n.
A non-nucleoside reverse transcriptase inhibitor.
ΘΚΠ
the world > health and disease > healing > medicines or physic > medicines for specific purpose > preparations treating or preventing specific ailments > [noun] > for HIV infection
dideoxycytidine1965
azidothymidine1974
dideoxyinosine1975
AZT1985
ddC1987
Retrovir1987
zidovudine1987
ddI1989
didanosine1990
nevirapine1991
zalcitabine1991
non-nucleoside1993
1993 Nature 18 Feb. 650/1 Therapy relying on inhibitors of reverse transcriptase by nucleosides..and by non-nucleosides like pyridinones or nevirapine may exert different selection pressures on this enzyme.
2001 Antiviral Res. 52 189 Severe hepatotoxicity appears in around 10% of subjects who began triple combinations including either protease inhibitors or non-nucleosides.
This is a new entry (OED Third Edition, September 2003; most recently modified version published online March 2022).
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adj.n.1987