non-peptideadj.n.

Brit.

/nɒnˈpɛptʌɪd/, U.S.

/nɑnˈpɛpˌtaɪd/

Origin: Formed within English, by derivation. Etymons: non- prefix, peptide n.

Etymology: < non- prefix + peptide n.

Biochemistry.

A. adj.

Of a molecule: that is not a peptide, spec. that does not contain peptide groups or peptide bonds. Of a bond or linkage: not a peptide bond.

ΚΠ

1942 Proc. Royal Soc. B. 131 148 If the number of free terminal carboxyl-groups is in excess of one there must be a number, equal to this excess, of dicarboxylic acid second carboxyl groups associated in some form of non-peptide linkage.

1973 Hoppe-Seyler's Zeitschr. f. Physiol. Chem. 354 613 (title) The effect of a non-peptide interchain crosslink on the reoxidation of reduced insulin.

1990 Protein Engin. 4 1/1 It is extremely difficult to discover nonpeptide compounds based solely on peptide-derived information.

2002 Molecular Endocrinol. 16 600 Antagonist binding (cyclic or linear, peptide or nonpeptide) was unaffected.

B. n.

A non-peptide molecule.

ΚΠ

1982 Jrnl. Pharmacol. & Exper. Therapeutics 222 612 The endogenous opioids appear to be a mixture of endorphin-like peptides as well as nonpeptides.

1991 Sci. News 27 Apr. 270/1 The Abbott team made a ‘nonpeptide’ that acts as a renin inhibitor but escapes recognition by peptide-degrading enzymes.

2001 Jrnl. Medicinal Chem. 44 4082 A small database of peptides and non-peptides known to have GHS activity was used to generate and assess a 3D pharmacophore.

This is a new entry (OED Third Edition, December 2003; most recently modified version published online March 2022).

单词	non-peptide
释义	non-peptideadj.n. Brit. /nɒnˈpɛptʌɪd/, U.S. /nɑnˈpɛpˌtaɪd/ Origin: Formed within English, by derivation. Etymons: non- prefix, peptide n. Etymology: < non- prefix + peptide n. Biochemistry. A. adj. Of a molecule: that is not a peptide, spec. that does not contain peptide groups or peptide bonds. Of a bond or linkage: not a peptide bond. ΚΠ 1942 Proc. Royal Soc. B. 131 148 If the number of free terminal carboxyl-groups is in excess of one there must be a number, equal to this excess, of dicarboxylic acid second carboxyl groups associated in some form of non-peptide linkage. 1973 Hoppe-Seyler's Zeitschr. f. Physiol. Chem. 354 613 (title) The effect of a non-peptide interchain crosslink on the reoxidation of reduced insulin. 1990 Protein Engin. 4 1/1 It is extremely difficult to discover nonpeptide compounds based solely on peptide-derived information. 2002 Molecular Endocrinol. 16 600 Antagonist binding (cyclic or linear, peptide or nonpeptide) was unaffected. B. n. A non-peptide molecule. ΚΠ 1982 Jrnl. Pharmacol. & Exper. Therapeutics 222 612 The endogenous opioids appear to be a mixture of endorphin-like peptides as well as nonpeptides. 1991 Sci. News 27 Apr. 270/1 The Abbott team made a ‘nonpeptide’ that acts as a renin inhibitor but escapes recognition by peptide-degrading enzymes. 2001 Jrnl. Medicinal Chem. 44 4082 A small database of peptides and non-peptides known to have GHS activity was used to generate and assess a 3D pharmacophore. This is a new entry (OED Third Edition, December 2003; most recently modified version published online March 2022). < adj.n.1942
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