non-steroidaladj.n.

Brit.

/ˌnɒnstɛˈrɔɪdl/,

/ˌnɒnstɪəˈrɔɪdl/, U.S.

/ˌnɑnstɛˈrɔɪd(ə)l/,

/ˌnɑnstɪˈrɔɪd(ə)l/

Origin: Formed within English, by derivation. Etymons: non- prefix, steroidal adj. at steroid n. Derivatives

Etymology: < non- prefix + steroidal adj. at steroid n. Derivatives.

Pharmacology.

A. adj.

1. That does not have the chemical structure of a steroid; spec. that is not an adrenal or gonadal steroid hormone.

ΚΠ

1952 Science 4 Apr. 377/2 Incubation of their blood..with nonsteroidal microcrystals (e.g. sulfonamides), had only slight effects on the level of eosinophils.

1965 Acta Pharmacologica et Toxicologica 23 365 The search for new non-steroidal oestrogens has mainly been concentrated on derivatives of stilbene.

1977 Ann. Internal Med. 86 222/1 The most studied nonsteroidal immunosuppressive agents have been azathioprine and cyclophosphamide.

2002 Jrnl. Pharmacol. & Exper. Therapeutics 302 584 Tamoxifen, a nonsteroidal antiestrogen, is used widely in the treatment of breast cancer.

2. That does not use, contain, or involve steroids (spec. corticosteroids or sex steroids); (also) that uses or involves non-steroidal anti-inflammatory drugs (see Compounds).

ΚΠ

1963 Arthritis & Rheumatism 6 36 The anti-UV-erythema efficacy is closely correlated with and highly predictive of a nonsteroidal kind of antirheumatic efficacy.

1981 Brit. Jrnl. Obstetr. & Gynaecol. 88 919 Naloxone may provide the basis for a non-steroidal treatment of climacteric flushing attacks.

1987 Today's Health Apr. 52/1 Protecting the mucosa from the irritating effects of long-term non-steroidal treatment.

1995 Animals' Voice Winter 16 If nonsteroidal therapy is ineffective then corticosteroids, such as prednisone or prednisolone, are sometimes prescribed.

1999 Daily Tel. 8 June 20/3 She takes..two puffs of Bricanyl, her non-steroidal inhaler, up to four times a day.

B. n.

A non-steroidal anti-inflammatory drug.

ΘΚΠ

the world > health and disease > healing > medicines or physic > medicines for specific purpose > preparations allaying inflammation > [noun]

antiphlogistic1744

non-steroidal1982

1982 Rheumatol. & Rehabilitation 21 187 (title) Non-steroidals ineffective in OA?

2001 Oncologist 6 353 Other suggested beneficial effects of estrogen such as colon cancer prevention can be approached by the use of aspirin or the non-steroidals.

Compounds

non-steroidal anti-inflammatory agent n. = non-steroidal anti-inflammatory drug n.

ΚΠ

1963 Arthritis & Rheumatism 6 44 CI-440 would seem to be the most potent nonsteroidal anti-inflammatory agent yet reported.

1997 B. Rowlands Which? Guide Complementary Med. 109 The herbs may contain..conventional drugs (corticosteroids, paracetamol, non-steroidal anti-inflammatory agents, benzodiazepines).

non-steroidal anti-inflammatory drug n. any of a group of non-steroidal compounds having anti-inflammatory effects (chiefly inhibition of prostaglandin synthesis), used especially in the treatment of arthritis and other inflammatory musculoskeletal disorders, as analgesics for mild to moderate pain (of headache, dysmenorrhoea, etc.), and as antipyretics; abbreviated NSAID.

ΚΠ

1964 S. Garattini & M. N. G. Dukes (title) International symposium on non-steroidal anti-inflammatory drugs.

1966 Proc. Soc. Exper. Biol. & Med. 123 707 (title) Effect of non-steroidal anti-inflammatory drugs in the Evans Blue pleural effusion.

2002 Ann. Allergy, Asthma & Immunol. 88 331 Adverse reactions to nonsteroidal anti-inflammatory drugs (NSAIDs) are very common problems.

This is a new entry (OED Third Edition, June 2003; most recently modified version published online March 2022).

单词	non-steroidal
释义	non-steroidaladj.n. Brit. /ˌnɒnstɛˈrɔɪdl/, /ˌnɒnstɪəˈrɔɪdl/, U.S. /ˌnɑnstɛˈrɔɪd(ə)l/, /ˌnɑnstɪˈrɔɪd(ə)l/ Origin: Formed within English, by derivation. Etymons: non- prefix, steroidal adj. at steroid n. Derivatives Etymology: < non- prefix + steroidal adj. at steroid n. Derivatives. Pharmacology. A. adj. 1. That does not have the chemical structure of a steroid; spec. that is not an adrenal or gonadal steroid hormone. ΚΠ 1952 Science 4 Apr. 377/2 Incubation of their blood..with nonsteroidal microcrystals (e.g. sulfonamides), had only slight effects on the level of eosinophils. 1965 Acta Pharmacologica et Toxicologica 23 365 The search for new non-steroidal oestrogens has mainly been concentrated on derivatives of stilbene. 1977 Ann. Internal Med. 86 222/1 The most studied nonsteroidal immunosuppressive agents have been azathioprine and cyclophosphamide. 2002 Jrnl. Pharmacol. & Exper. Therapeutics 302 584 Tamoxifen, a nonsteroidal antiestrogen, is used widely in the treatment of breast cancer. 2. That does not use, contain, or involve steroids (spec. corticosteroids or sex steroids); (also) that uses or involves non-steroidal anti-inflammatory drugs (see Compounds). ΚΠ 1963 Arthritis & Rheumatism 6 36 The anti-UV-erythema efficacy is closely correlated with and highly predictive of a nonsteroidal kind of antirheumatic efficacy. 1981 Brit. Jrnl. Obstetr. & Gynaecol. 88 919 Naloxone may provide the basis for a non-steroidal treatment of climacteric flushing attacks. 1987 Today's Health Apr. 52/1 Protecting the mucosa from the irritating effects of long-term non-steroidal treatment. 1995 Animals' Voice Winter 16 If nonsteroidal therapy is ineffective then corticosteroids, such as prednisone or prednisolone, are sometimes prescribed. 1999 Daily Tel. 8 June 20/3 She takes..two puffs of Bricanyl, her non-steroidal inhaler, up to four times a day. B. n. A non-steroidal anti-inflammatory drug. ΘΚΠ the world > health and disease > healing > medicines or physic > medicines for specific purpose > preparations allaying inflammation > [noun] antiphlogistic1744 non-steroidal1982 1982 Rheumatol. & Rehabilitation 21 187 (title) Non-steroidals ineffective in OA? 2001 Oncologist 6 353 Other suggested beneficial effects of estrogen such as colon cancer prevention can be approached by the use of aspirin or the non-steroidals. Compounds non-steroidal anti-inflammatory agent n. = non-steroidal anti-inflammatory drug n. ΚΠ 1963 Arthritis & Rheumatism 6 44 CI-440 would seem to be the most potent nonsteroidal anti-inflammatory agent yet reported. 1997 B. Rowlands Which? Guide Complementary Med. 109 The herbs may contain..conventional drugs (corticosteroids, paracetamol, non-steroidal anti-inflammatory agents, benzodiazepines). non-steroidal anti-inflammatory drug n. any of a group of non-steroidal compounds having anti-inflammatory effects (chiefly inhibition of prostaglandin synthesis), used especially in the treatment of arthritis and other inflammatory musculoskeletal disorders, as analgesics for mild to moderate pain (of headache, dysmenorrhoea, etc.), and as antipyretics; abbreviated NSAID. ΚΠ 1964 S. Garattini & M. N. G. Dukes (title) International symposium on non-steroidal anti-inflammatory drugs. 1966 Proc. Soc. Exper. Biol. & Med. 123 707 (title) Effect of non-steroidal anti-inflammatory drugs in the Evans Blue pleural effusion. 2002 Ann. Allergy, Asthma & Immunol. 88 331 Adverse reactions to nonsteroidal anti-inflammatory drugs (NSAIDs) are very common problems. This is a new entry (OED Third Edition, June 2003; most recently modified version published online March 2022). < adj.n.1952
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