oestrogenestrogenn.
/ˈiːstrədʒ(ə)n/, /ˈɛstrədʒ(ə)n/, U.S. /ˈɛstrədʒ(ə)n/ Biochemistry and Physiology.
Any of a group of naturally occurring hormones and synthetic compounds that are capable of regulating sexual development and function in female vertebrates (including maintenance of the oestrous or menstrual cycle), and which are used in contraceptives and in the treatment of menopausal symptoms and ovarian disorders; (also) such compounds as a class.In earliest use a brand name for a hormonal preparation derived from human placentas.The naturally occurring oestrogens are eighteen-carbon steroids (cf. oestrane n.), and are produced by the ovary, placenta, adrenal gland, and testis.
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the world > life > biology > substance > process stimulators or inhibitors > hormone > [noun] > other hormones
thyro-iodine1896
parathormone1925
parathyroid hormone1925
oestrin1926
oestrogen1927
relaxin1930
theelin1930
prolan1931
galactin1932
inhibin1932
prolactin1932
oestriol1933
oestrone1933
oestradiol1934
adrenocorticotrophin1943
pancreozymin1943
ADH1945
adrenocorticotropin1945
cortisone1949
mineralocorticoid1950
electrocortin1953
aldosterone1954
angiotensin1958
melatonin1958
calcitonin1961
zeranol1971
amylin1988
adiponectin1999
adipokine2001
1927 Official Gaz. (U.S. Patent Office) 22 Nov. 788/1 Parke, Davis & Company, Detroit, Michigan... Estrogen... Extract of gland tissue for use in the treatment of various types of ovarian disfunctions. Claims use since May 25, 1927.
1928 Endocrinology 12 153 Estrogen is a colloidal solution of human placental extract containing ovarian hormone.
1936 Jrnl. Amer. Med. Assoc. 10 Oct. 1223/2 ‘Estrogen’ is a registered trade mark belonging to Parke, Davis and Company... This firm has commendably agreed to relinquish its proprietary rights in the name on its adoption by the Council as a generic term.
1943 Endeavour 2 29/2 This soon led..to the synthesis of artificial oestrogens of extraordinary potency.
1960 Which? Feb. 24/1 Oestrogens..seem to have been incorporated into face creams without any direct evidence that they could affect the skin.
1988 What Diet & Lifestyle Apr.–May 19/1 Women smokers are more prone to osteoporosis..because they produce less of the protective female hormone, oestrogen.
2000 N.Y. Times 9 May f6/1 Although the minipill is slightly less effective than the combination pills, it can be used by women, like those who are breast-feeding, who cannot take estrogen.
Compounds
C1.
a.
oestrogen effect n.
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1957 Times 2 Dec. (Agric. Suppl.) p. vi/4 A source of greater fear to those familiar with oestrogen effects is the inhalation of dust from a concentrated premix.
1972 Endocrinology 91 1273 (heading) Early estrogen effects on lipid metabolism in the rat uterus.
2000 Menopause 7 14 Of the species examined for estrogen effects on vasomotor symptoms (guinea pig, mouse, rat, and monkey), only rats and monkeys show evidence of hot flashes associated with loss of reproductive function.
oestrogen excretion n.
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1939 Q. Rev. Biol. 14 462/1 In considering the evidence from studies on oestrogen excretion, the authors nowhere mention that excretion studies which do not involve the freeing of ‘bound’ oestrogen are of negligible significance.
1972 Brit. Vet. Jrnl. 128 565 Urinary oestrogen excretion has been studied during the oestrus cycle in a variety of domestic animals.
2003 Gen. & Compar. Endocrinol. 131 274 The pattern of fecal estrogen excretion was strongly related to the sex of the fetus in utero.
oestrogen ointment n.
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1960 Which? Feb. 24/2 In aged women..it was claimed that treatment with oestrogen ointment had an effect.
1979 Maturitas 1 183 Good tolerance of estrogen therapy with significantly elevated estrogen concentrations in plasma can be obtained transcutaneously in the form of estrogen ointments.
2000 Drug Topics (Nexis) 20 Nov. 54 We're finding that postmenopausal women are getting relief from dryness when they apply estrogen ointments to the vaginal wall.
oestrogen pill n.
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1972 F. Warner Maquettes 44 Oestrogen-pills on prescription.
1991 N. Gordimer Jump & other Stories (1992) 58 How old? The age of a woman without oestrogen pills, hair tint charts, sun-screens and anti-wrinkle creams.
b.
oestrogen-induced adj.
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1956 Nature 10 Mar. 478/2 Progesterone..prevents oestrogen-induced abdominal fibroids.
1991 Lancet 3 Aug. p. iii The protective effect of exogenous progestagen against oestrogen-induced endometrial hyperplasia.
oestrogen-secreting adj.
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1948 L. C. Martin & M. Hynes Clin. Endocrinol. ix. 191 Œstrogen-secreting ovarian tumours composed of cells resembling those of the membrana granulosa of the Graafian follicle.
1988 Philos. Trans. (Royal Soc.) B. 322 64 The oestrogen-secreting theca cells of the mature ovary.
2000 Endocrine Jrnl. 47 723 We examined clinical, endocrinological and molecular biological aspects of an estrogen-secreting adrenal carcinoma in an 18-month-old male.
oestrogen-treated adj.
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1952 Proc. Royal Soc. 1951–2 B. 139 359 A testicular stimulating action of sulphadimidine in oestrogen-treated cockerels has been described by Kumaran & Turner.
1990 Nucleic Acids Res. 18 4158/2 Preparations of liver nuclei from hormone-naive or estrogen-treated chicks were digested with varying amounts of DNaseI.
C2.
oestrogen replacement therapy n. Medicine treatment with oestrogens in (chiefly menopausal) women who lack the normal ovarian source of these hormones; spec. treatment with an oestrogen without a progestagen.
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1958 Ann. Internal Med. 48 95 (title) Estrogen replacement therapy in women with coronary atherosclerosis.
1980 Obstetrics & Gynecol. 56 349 This study and the review of the available data reported in the literature..stress the importance of appropriate estrogen and progestogen dosage to avoid the hazards of abnormal endometrial pattern in young patients receiving estrogen replacement therapy.
2000 Med. Jrnl. Austral. 172 226 Oestrogen replacement therapy remains the first choice for prevention of bone loss in early postmenopausal women with low bone density.
oestrogen therapy n. treatment with oestrogen; oestrogen replacement therapy.
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the world > health and disease > healing > medical treatment > treatment by medicine or drug > [noun] > treatment with specific substances > hormone replacement therapy
oestrogen therapy1946
hormone replacement1967
hormonal replacement1968
HRT1973
1946 Philos. Trans. (Royal Soc.) B. 231 505 Oestrogen therapy has been used successfully for the stimulation of growth in the buccal mucous membrane of menopausal women.
1974 Jrnl. Amer. Med. Assoc. 4 Feb. 522/1 Patients with preexisting hyperlipemia should probably not receive estrogen therapy.
1990 Sunday Express Mag. 11 Feb. 45/1 Oestrogen therapy (HRT) for women is increasingly prescribed to stave off post-menopausal symptoms.
This entry has been updated (OED Third Edition, March 2004; most recently modified version published online March 2022).
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n.1927