osteoclastn.

Brit.

/ˈɒstɪə(ʊ)klɑːst/,

/ˈɒstɪə(ʊ)klast/, U.S.

/ˈɑstioʊˌklæst/

Forms: 1800s osteoklast, 1800s– osteoclast.

Origin: Formed within English, by compounding. Etymons: osteo- comb. form, -clast comb. form.

Etymology: < osteo- comb. form + -clast comb. form. In sense 1 after German Osteoklast (R. A. von Kölliker 1872, in Verhandl. der Physikalisch-Med. Ges. Würzburg 2 243). In sense 2 probably after Italian osteoclaste (1875 or earlier). Compare earlier osteoclasis n.

1. Histology. A multinucleated giant cell of haematopoietic stem cell origin that carries out resorption of bone.

ΘΚΠ

the world > life > the body > structural parts > bone or bones > substance of bones > [noun] > cell or corpuscle of

bone corpuscle1842

bone cell1846

myeloplax1866

osteoblast1867

astroblast1871

osteoclast1872

myeloplaque1877

polykaryocyte1890

myeloplast1891

astrocyte1893

osteocyte1918

1872 Monthly Microsc. Jrnl. July 134 He [sc. Kölliker] designates them ‘osteoclasts’ (or osteophages).

1875 Encycl. Brit. I. 856/2 The product of the formation of osseous tissue by the agency of the osteo-blasts, and of its absorption or destruction by the action of the osteo-klasts.

1894 Philos. Trans. (Royal Soc.) B. 185 317 The hollowing-out of spaces in the first bone spicules by the osteoclasts.

1939 T. L. Green Pract. Animal Biol. iii. 242 Next to the modified cartilage areas ossification is taking place through the agency of cells known as osteoblasts and osteoclasts.

1992 Daily Tel. 4 July 4/4 Lack of hormone oestrogen leads to an over production of bone scavenger cells, osteoclasts.

2. Surgery. An instrument for effecting osteoclasis. Now rare.

ΚΠ

1887 A. H. Buck Ref. Handbk. Med. Sci. V. 385/2 In 1846 Rizzoli devised an osteoclast for fracturing bone.

1890 E. H. Bradford & R. W. Lovett Treat. Orthopedic Surg. xx. 684 Mechanical fracture is made feasible by the use of osteoclasts, of which the one of Rizzoli is the most convenient.

1895 Catal. Surg. Instruments (Arnold & Sons) 109 Osteoclast, as used at Bartholomew's, large size for adults.

1904 R. Whitman Orthopedic Surg. (ed. 2) xvi. 573 Osteoclasis, by means of the Grattan osteoclast, is an effective operation. With this instrument the bone may be broken above the condyles at the desired point.

1930 Lancet 27 Sept. 690 (title) Osteoclast with screw control.

This entry has been updated (OED Third Edition, September 2004; most recently modified version published online March 2022).

单词	osteoclast
释义	osteoclastn. Brit. /ˈɒstɪə(ʊ)klɑːst/, /ˈɒstɪə(ʊ)klast/, U.S. /ˈɑstioʊˌklæst/ Forms: 1800s osteoklast, 1800s– osteoclast. Origin: Formed within English, by compounding. Etymons: osteo- comb. form, -clast comb. form. Etymology: < osteo- comb. form + -clast comb. form. In sense 1 after German Osteoklast (R. A. von Kölliker 1872, in Verhandl. der Physikalisch-Med. Ges. Würzburg 2 243). In sense 2 probably after Italian osteoclaste (1875 or earlier). Compare earlier osteoclasis n. 1. Histology. A multinucleated giant cell of haematopoietic stem cell origin that carries out resorption of bone. ΘΚΠ the world > life > the body > structural parts > bone or bones > substance of bones > [noun] > cell or corpuscle of bone corpuscle1842 bone cell1846 myeloplax1866 osteoblast1867 astroblast1871 osteoclast1872 myeloplaque1877 polykaryocyte1890 myeloplast1891 astrocyte1893 osteocyte1918 1872 Monthly Microsc. Jrnl. July 134 He [sc. Kölliker] designates them ‘osteoclasts’ (or osteophages). 1875 Encycl. Brit. I. 856/2 The product of the formation of osseous tissue by the agency of the osteo-blasts, and of its absorption or destruction by the action of the osteo-klasts. 1894 Philos. Trans. (Royal Soc.) B. 185 317 The hollowing-out of spaces in the first bone spicules by the osteoclasts. 1939 T. L. Green Pract. Animal Biol. iii. 242 Next to the modified cartilage areas ossification is taking place through the agency of cells known as osteoblasts and osteoclasts. 1992 Daily Tel. 4 July 4/4 Lack of hormone oestrogen leads to an over production of bone scavenger cells, osteoclasts. 2. Surgery. An instrument for effecting osteoclasis. Now rare. ΚΠ 1887 A. H. Buck Ref. Handbk. Med. Sci. V. 385/2 In 1846 Rizzoli devised an osteoclast for fracturing bone. 1890 E. H. Bradford & R. W. Lovett Treat. Orthopedic Surg. xx. 684 Mechanical fracture is made feasible by the use of osteoclasts, of which the one of Rizzoli is the most convenient. 1895 Catal. Surg. Instruments (Arnold & Sons) 109 Osteoclast, as used at Bartholomew's, large size for adults. 1904 R. Whitman Orthopedic Surg. (ed. 2) xvi. 573 Osteoclasis, by means of the Grattan osteoclast, is an effective operation. With this instrument the bone may be broken above the condyles at the desired point. 1930 Lancet 27 Sept. 690 (title) Osteoclast with screw control. This entry has been updated (OED Third Edition, September 2004; most recently modified version published online March 2022). < n.1872
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