orthotopicadj.

1917 Proc. National Acad. Sci. U.S.A. 3 245 First the limb buds were placed either in their natural location in another embryo after removal of the normal bud (orthotopic transplantation) or else in some other region of the body..(heterotopic transplantation).

1958 Immunology 1 46 The survival times of successive sets of orthotopic scale (skin) homografts revealed that increasing systematic immunity develops rapidly in stepwise fashion.

1968 National Observer (U.S.) 29 Jan. 4/4 Dr. Starzl performed the first orthotopic liver transplant, in which the diseased liver is removed and another implanted, in 1963.

1988 Brit. Med. Jrnl. 21 May 1445/1 Orthotopic liver transplantation is still controversial for non-resectable hepatocellular carcinoma.

1993 Brit. Jrnl. Surg. 80 316/2 In the present patient the ectopic thyroid tissue was separate from the coincidental gastric carcinoma and the orthotopic thyroid gland appeared to function normally.

2003 Jrnl. Cardiac Surg. 18 183 The aim of the study was to evaluate long-term results for patients who underwent orthotopic heart transplantation.

1921 Jrnl. Exper. Zool. 32 61 The shoulder-girdle in orthotopically grafted limbs is derived in part from the host and in part from the transplanted tissue.

1974 Nature 11 Oct. 553/1 When solid tissue allografts are transplanted orthotopically to alien hosts they are rejected with a characteristic tempo and vigour that depends primarily on the immunogenetic disparity between donor and host.

1993 Brit. Jrnl. Surg. 80 76/1 All grafts were protected from ischaemia using UW solution and transplanted orthotopically.