organoidadj.n.

1852 N. Brit. Rev. Aug. 139 No sooner does that cease to be alive than it falls down into masses of fibrin jelly, and their likes; exposed to moisture and air, these in their turn speedily fall down into still less organoid compounds.

1857 R. G. Mayne Expos. Lexicon Med. Sci. (1860) Organoides,..applied to a mineral which presents the structure of an organised body; for example, to the wood of a madrepore, as the Chalcedon organoïdes: organoid.

1876 J. S. Bristowe Treat. Theory & Pract. Med. i. i. 73 ‘Organoid tumours’..composed of a fibrous framework, or stroma, so arranged as to form a series of loculi, and of groups of cells which are contained in dense masses within them.

1953 H. I. Firminger in F. Homburger & W. H. Fishman Physiopathol. Cancer ix. 152 Testicular teratoma occur spontaneously in cocks and, like those in horses are organoid and apparently benign.

1892 Amer. Naturalist 26 665 He [sc. Verworn] compares the rôle of the nucleus to that of a cell organoid.

1906 M. Hartog in Cambr. Nat. Hist. I. ii. 44 (note) The terms ‘organoid,’ ‘organella,’ have been introduced to designate a definite portion of a Protist specialised for a definite function; the term ‘organ’ being reserved for a similarly specialised group of cells or tissues in a Metazoon or Metaphyte.

1930 A. A. Maximow & W. Bloom Text-bk. Histol. i. 5 The constituents of the cytoplasm..may be classified as the organoids and the inclusions. The organoids are structures..which are probably endowed with the ability to divide..in contrast to the inclusions which are passive, lifeless, temporary constitutents of the cell. The organoids comprise the mitochondria, the Golgi apparatus, the centrioles, and fibrils.

1956 Anat. Rec. 125 481 The presence of mitochondria in smooth muscle was described by Cowdry..long after these organoids had been studied in other tissues.

1957 H. S. D. Garven Student's Histol. i. 19 The centrosome... Not infrequently this organoid is found lying embedded in the skein of the Golgi body.

1982 Proc. National Acad. Sci. U.S.A. 79 3213/2 Primary cultures of rat mammary epithelium were prepared... The resulting mammary ‘organoids’ consist of ductal and alveolar fragments containing epithelial and myoepithelial cells.

1989 Science 10 Nov. 747/2 With little more than some strands of Gore-Tex finer than an angel's hair, a supply of collagen, and a dash of heparin-binding growth factor-1, John Thompson and Thomas Macaig have what Thompson calls ‘a cauldron of all the right stuff to create an organ’. An ‘organoid’, really.

1990 Lancet 27 Jan. 220/2 The ‘organoid’, or artificial liver..has survived in the peritoneal cavity of a rat for several months.

1991 Calgary (Alberta) Herald (Nexis) 14 July c3 Dr. John Thompson..is head of a research team that has created the first working organoid consisting of masses of liver cells harvested from rats and wrapped in Gore-tex... The device was successfully implanted in lab rats.

1996 Atlanta Jrnl. (Nexis) 16 July 12 a At Emory University, Dr. Elliot Chaikof is working on what he calls an ‘organoid’, combining both biological and artificial elements into artificial limbs and body parts.