ototoxicadj.

Brit.

/ˌəʊtəʊˈtɒksɪk/, U.S.

/ˌoʊdoʊˈtɑksɪk/

Origin: Formed within English, by compounding. Etymons: oto- comb. form, -toxic comb. form.

Etymology: < oto- comb. form + -toxic comb. form.

Causing damage to the inner ear, with impairment of auditory or vestibular function.

ΘΚΠ

the world > health and disease > ill health > a disease > disorders of ear > [adjective] > ototoxic

ototoxic1951

1951 Trans. 10th Conf. Chemotherapy of Tuberculosis 224 The growing list of tuberculostatic antibiotics which have an ototoxic action..suggests that still other substances derived from Streptomyces may be expected to show a similar toxicity.

1967 H. Busch & M. Lane Chemotherapy v. 86/2 The ototoxic effect is exerted primarily on the cochlear division of the 8th nerve.

1974 Arch. Pathol. 96 304/1 Methyl mercury is a unique ototoxic agent.

1986 New Yorker 10 Feb. 67/1 He had used something that was ototoxic and had made himself deaf in one ear.

1993 N.Y. Times 23 Mar. c6/3 One study, led by..a cell biologist at the London institute, looked at guinea pigs whose inner-ear hair cells were killed with an ototoxic antibiotic.

1999 Proc. National Acad. Sci. U.S.A. 96 4084/1 Hearing loss is most often the result of hair-cell degeneration due to genetic abnormalities or ototoxic and traumatic insults.

Derivatives

ˌototoxˈicity n. the tendency of certain drugs or other chemicals to cause damage to the inner ear; the property of being ototoxic.

ΘΚΠ

the world > health and disease > ill health > a disease > disorders of ear > [noun] > ototoxic quality

ototoxicity1951

1951 Trans. 10th Conf. Chemotherapy of Tuberculosis 224 (heading) Ototoxicity of hydroxystreptomycin.

1975 Nature 3 Jan. 45/1 Kanamycin ototoxicity yields such cochlear lesions that histological and audiometric measures are well correlated.

1993 Brit. Med. Jrnl. (BNC) 6 Feb. 392 The number of occasions when prolonged treatment with aminoglycosides is required is small, but in these cases the risk of ototoxicity is high.

1997 National Geographic Traveler July 36/1 Hearing and Vestibular: earache, tinnitus, deafness, ototoxicity.

This entry has been updated (OED Third Edition, September 2004; most recently modified version published online March 2022).

单词	ototoxic
释义	ototoxicadj. Brit. /ˌəʊtəʊˈtɒksɪk/, U.S. /ˌoʊdoʊˈtɑksɪk/ Origin: Formed within English, by compounding. Etymons: oto- comb. form, -toxic comb. form. Etymology: < oto- comb. form + -toxic comb. form. Causing damage to the inner ear, with impairment of auditory or vestibular function. ΘΚΠ the world > health and disease > ill health > a disease > disorders of ear > [adjective] > ototoxic ototoxic1951 1951 Trans. 10th Conf. Chemotherapy of Tuberculosis 224 The growing list of tuberculostatic antibiotics which have an ototoxic action..suggests that still other substances derived from Streptomyces may be expected to show a similar toxicity. 1967 H. Busch & M. Lane Chemotherapy v. 86/2 The ototoxic effect is exerted primarily on the cochlear division of the 8th nerve. 1974 Arch. Pathol. 96 304/1 Methyl mercury is a unique ototoxic agent. 1986 New Yorker 10 Feb. 67/1 He had used something that was ototoxic and had made himself deaf in one ear. 1993 N.Y. Times 23 Mar. c6/3 One study, led by..a cell biologist at the London institute, looked at guinea pigs whose inner-ear hair cells were killed with an ototoxic antibiotic. 1999 Proc. National Acad. Sci. U.S.A. 96 4084/1 Hearing loss is most often the result of hair-cell degeneration due to genetic abnormalities or ototoxic and traumatic insults. Derivatives ˌototoxˈicity n. the tendency of certain drugs or other chemicals to cause damage to the inner ear; the property of being ototoxic. ΘΚΠ the world > health and disease > ill health > a disease > disorders of ear > [noun] > ototoxic quality ototoxicity1951 1951 Trans. 10th Conf. Chemotherapy of Tuberculosis 224 (heading) Ototoxicity of hydroxystreptomycin. 1975 Nature 3 Jan. 45/1 Kanamycin ototoxicity yields such cochlear lesions that histological and audiometric measures are well correlated. 1993 Brit. Med. Jrnl. (BNC) 6 Feb. 392 The number of occasions when prolonged treatment with aminoglycosides is required is small, but in these cases the risk of ototoxicity is high. 1997 National Geographic Traveler July 36/1 Hearing and Vestibular: earache, tinnitus, deafness, ototoxicity. This entry has been updated (OED Third Edition, September 2004; most recently modified version published online March 2022). < adj.1951
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