Pagetn.

Brit.

/ˈpadʒᵻt/, U.S.

/ˈpædʒət/

Origin: From a proper name. Etymon: proper name Paget.

Etymology: < the name of Sir James Paget (1814–99), English surgeon, who described the disease of the breast in 1874 (in St. Bartholomew's Hosp. Rep. 10 87) and the disease of bone in 1877 (see quot. 1877 at sense 1b).

Medicine.

1. Paget's disease n.

a. An eczematoid condition of the skin characterized by the presence of pathognomonic abnormal cells within the epidermis (see sense 2), frequently associated with an adenocarcinoma of underlying tissue and most commonly occurring in the female nipple.

ΘΚΠ

the world > health and disease > ill health > a disease > disorders of visible parts > skin disorders > [noun] > eczema

eczema1753

grocers' itch1799

washerwoman's itch1844

Paget's disease1880

cradle cap1890

weeping eczema1899

1880 Brit. Med. Jrnl. 24 Jan. 128/1 As attention was first called to it by Sir James Paget, he [sc. J. E. Erichsen] would suggest for it the name ‘Paget's disease’ of the nipple.

1896 N. Walker tr. P. G. Unna Histopathol. Dis. Skin 743 The œdematous character of the cells in Paget's disease prevents the appearance of kerato-hyalin.

1923 Brit. Jrnl. Surg. 11 317 Carcinoma in the breast, with which Paget's disease of the nipple is usually associated, is a primary carcinoma of the breast epithelium.

1954 Jrnl. Obstetr. & Gynæcol. 61 758 (title) Histochemical characterization of the specific cells in Paget's disease of the vulva.

1966 G. P. Wright & W. S. Symmers Systemic Pathol. I. xxviii. 996/2 Patients with Paget's disease are still very likely to be treated for supposed dermatitis of the nipple.

2002 Top Santé Feb. 6/1 Your feature mentioned a rare form [of breast cancer] called Paget's disease, which starts with a rash similar to eczema.

b. A disorder of bone occurring chiefly in the elderly and characterized by abnormal bone remodelling, with increased osteoclastic (and, later, osteoblastic) activity, esp. in the skull, the spine, and the pelvis, resulting in weakening of the involved bone or bones, neurological complications, and (rarely) osteosarcoma. Also called osteitis deformans n.

ΘΚΠ

the world > health and disease > ill health > a disease > diseases of tissue > disorders of bones > [noun] > other bone disorders

osteocachexy1857

osteitis deformans1877

Paget's disease1889

megalacria1891

osteochondritis dissecans1895

osteogenesis imperfecta1899

von Recklinghausen's disease1910

Albright's syndrome1940

fibrogenesis imperfecta ossium1952

pycnodysostosis1963

McCune–Albright syndrome1966

1877 Guy's Hosp. Rep. 22 337 (heading) Osteoporosis or Paget's osteitis deformans.]

1889 Index-Catal. Libr. Surg.-General's Office, U.S. Army X. 353/2 (heading) Paget's disease of the bones. See osteitis deformans.

1939 Times 18 May 4/6 Dr. Alexander Wilson said that Mr. Desnos had Paget's disease—the bones of his skull were brittle and at least 50 per cent. softer than a normal skull.

1963 Lancet 5 Jan. 34/2 In Paget's disease stones are formed as a result of increased excretion of calcium due to increased turnover of bone.

1974 R. Passmore & J. S. Robson Compan. Med. Stud. III. xxvi. 17/2 Paget's disease is rarely a painful disorder in the absence of complications such as fracture, tumour or arthritis.

1995 Independent 11 Jan. 6/7 Egil Skalla-Grimsson, who died in about 990AD and was so physically menacing and irritable that he became the subject of an Icelandic saga, may have suffered from Paget's disease, when the bones and skull become grossly deformed.

2. Paget cell n. (also Paget's cell) an abnormal cell with abundant clear cytoplasm and enlarged, hyperchromatic nucleus, found within in the epidermis in Paget's disease (sense 1a).

ΘΚΠ

the world > health and disease > ill health > a disease > diseases of tissue > [noun] > abnormal or morbid tissue > cell characteristic of

myelocyte1891

mast cell1893

myeloblast1904

Paget cell1910

Sternberg–Reed1922

Reed–Sternberg cell1939

squame1949

1910 Jrnl. Cutaneous Dis. 28 383 The epidermis..contained many of the large round, so-called Paget cells.

1917 Lancet 7 Apr. 519/2 The degenerate deeper layers of the epidermis..contain the large clear cells known as Paget's cells.

1974 R. Passmore & J. S. Robson Compan. Med. Stud. III. xxx. 9/2 Some believe that the Paget cells represent intra-epidermal spread of this [sc. cancer].

1984 J. R. Tighe & D. R. Davies Pathol. (ed. 4) xxi. 203 The epithelium of the nipple is invaded by large pale-staining cells (Paget's cells).

1999 Brit. Jrnl. Dermatol. 141 146 A vulval biopsy showed Paget's cells in the epidermis.

This entry has been updated (OED Third Edition, March 2005; most recently modified version published online March 2022).

单词	paget
释义	Pagetn. Brit. /ˈpadʒᵻt/, U.S. /ˈpædʒət/ Origin: From a proper name. Etymon: proper name Paget. Etymology: < the name of Sir James Paget (1814–99), English surgeon, who described the disease of the breast in 1874 (in St. Bartholomew's Hosp. Rep. 10 87) and the disease of bone in 1877 (see quot. 1877 at sense 1b). Medicine. 1. Paget's disease n. a. An eczematoid condition of the skin characterized by the presence of pathognomonic abnormal cells within the epidermis (see sense 2), frequently associated with an adenocarcinoma of underlying tissue and most commonly occurring in the female nipple. ΘΚΠ the world > health and disease > ill health > a disease > disorders of visible parts > skin disorders > [noun] > eczema eczema1753 grocers' itch1799 washerwoman's itch1844 Paget's disease1880 cradle cap1890 weeping eczema1899 1880 Brit. Med. Jrnl. 24 Jan. 128/1 As attention was first called to it by Sir James Paget, he [sc. J. E. Erichsen] would suggest for it the name ‘Paget's disease’ of the nipple. 1896 N. Walker tr. P. G. Unna Histopathol. Dis. Skin 743 The œdematous character of the cells in Paget's disease prevents the appearance of kerato-hyalin. 1923 Brit. Jrnl. Surg. 11 317 Carcinoma in the breast, with which Paget's disease of the nipple is usually associated, is a primary carcinoma of the breast epithelium. 1954 Jrnl. Obstetr. & Gynæcol. 61 758 (title) Histochemical characterization of the specific cells in Paget's disease of the vulva. 1966 G. P. Wright & W. S. Symmers Systemic Pathol. I. xxviii. 996/2 Patients with Paget's disease are still very likely to be treated for supposed dermatitis of the nipple. 2002 Top Santé Feb. 6/1 Your feature mentioned a rare form [of breast cancer] called Paget's disease, which starts with a rash similar to eczema. b. A disorder of bone occurring chiefly in the elderly and characterized by abnormal bone remodelling, with increased osteoclastic (and, later, osteoblastic) activity, esp. in the skull, the spine, and the pelvis, resulting in weakening of the involved bone or bones, neurological complications, and (rarely) osteosarcoma. Also called osteitis deformans n. ΘΚΠ the world > health and disease > ill health > a disease > diseases of tissue > disorders of bones > [noun] > other bone disorders osteocachexy1857 osteitis deformans1877 Paget's disease1889 megalacria1891 osteochondritis dissecans1895 osteogenesis imperfecta1899 von Recklinghausen's disease1910 Albright's syndrome1940 fibrogenesis imperfecta ossium1952 pycnodysostosis1963 McCune–Albright syndrome1966 1877 Guy's Hosp. Rep. 22 337 (heading) Osteoporosis or Paget's osteitis deformans.] 1889 Index-Catal. Libr. Surg.-General's Office, U.S. Army X. 353/2 (heading) Paget's disease of the bones. See osteitis deformans. 1939 Times 18 May 4/6 Dr. Alexander Wilson said that Mr. Desnos had Paget's disease—the bones of his skull were brittle and at least 50 per cent. softer than a normal skull. 1963 Lancet 5 Jan. 34/2 In Paget's disease stones are formed as a result of increased excretion of calcium due to increased turnover of bone. 1974 R. Passmore & J. S. Robson Compan. Med. Stud. III. xxvi. 17/2 Paget's disease is rarely a painful disorder in the absence of complications such as fracture, tumour or arthritis. 1995 Independent 11 Jan. 6/7 Egil Skalla-Grimsson, who died in about 990AD and was so physically menacing and irritable that he became the subject of an Icelandic saga, may have suffered from Paget's disease, when the bones and skull become grossly deformed. 2. Paget cell n. (also Paget's cell) an abnormal cell with abundant clear cytoplasm and enlarged, hyperchromatic nucleus, found within in the epidermis in Paget's disease (sense 1a). ΘΚΠ the world > health and disease > ill health > a disease > diseases of tissue > [noun] > abnormal or morbid tissue > cell characteristic of myelocyte1891 mast cell1893 myeloblast1904 Paget cell1910 Sternberg–Reed1922 Reed–Sternberg cell1939 squame1949 1910 Jrnl. Cutaneous Dis. 28 383 The epidermis..contained many of the large round, so-called Paget cells. 1917 Lancet 7 Apr. 519/2 The degenerate deeper layers of the epidermis..contain the large clear cells known as Paget's cells. 1974 R. Passmore & J. S. Robson Compan. Med. Stud. III. xxx. 9/2 Some believe that the Paget cells represent intra-epidermal spread of this [sc. cancer]. 1984 J. R. Tighe & D. R. Davies Pathol. (ed. 4) xxi. 203 The epithelium of the nipple is invaded by large pale-staining cells (Paget's cells). 1999 Brit. Jrnl. Dermatol. 141 146 A vulval biopsy showed Paget's cells in the epidermis. This entry has been updated (OED Third Edition, March 2005; most recently modified version published online March 2022). < n.1880
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