英语词汇“p53 gene”的英英意思、用法、释义、翻译、读音、例句、短语、词组-英语词典

(The name of) a multifunctional protein involved in transcription and regulation of the cell cycle, including inhibition of abnormal cell proliferation, and thus implicated in tumour suppression (or, under certain circumstances, promotion). Also (more fully p53 gene): the gene encoding this protein, found (in humans) on chromosome 17.

ΚΠ

1979 A. DeLeo et al. in Proc. National Acad. Sci. U.S.A. 76 2420 All transformed mouse cells tested were found to express p53; these tests included chemically induced sarcomas, leukemias, spontaneously transformed fibroblasts, and cells transformed by simian virus 40 and murine sarcoma virus.

1988 Cancer Res. 48 2226 These results suggest that p53 levels are intimately related to an undifferentiated phenotype in neuroblastoma cells and support studies which relate p53 levels to the malignant phenotype in other tumor systems.

1991 EMBO Jrnl. 9 2885/1 Allelic degeneration of p53 is..strongly implicated in human carcinoma of the lung.

2002 U.S. News & World Rep. 14 Jan. 58/1 The researchers..meant to engineer mice with a p53 gene mutation like that in a human cancer.

单词	p53 gene
释义	> as lemmas p53 gene (The name of) a multifunctional protein involved in transcription and regulation of the cell cycle, including inhibition of abnormal cell proliferation, and thus implicated in tumour suppression (or, under certain circumstances, promotion). Also (more fully p53 gene): the gene encoding this protein, found (in humans) on chromosome 17. ΚΠ 1979 A. DeLeo et al. in Proc. National Acad. Sci. U.S.A. 76 2420 All transformed mouse cells tested were found to express p53; these tests included chemically induced sarcomas, leukemias, spontaneously transformed fibroblasts, and cells transformed by simian virus 40 and murine sarcoma virus. 1988 Cancer Res. 48 2226 These results suggest that p53 levels are intimately related to an undifferentiated phenotype in neuroblastoma cells and support studies which relate p53 levels to the malignant phenotype in other tumor systems. 1991 EMBO Jrnl. 9 2885/1 Allelic degeneration of p53 is..strongly implicated in human carcinoma of the lung. 2002 U.S. News & World Rep. 14 Jan. 58/1 The researchers..meant to engineer mice with a p53 gene mutation like that in a human cancer. extracted from p53n. < as lemmas
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