oxotremorinen.
/ˌɒksəʊˈtrɛməriːn/, U.S. /ˌɑksoʊˈtrɛməˌrin/ Pharmacology.
An active metabolite or derivative of tremorine that contains an oxo group, C4H8N·CH2·C≡C·CH2·NC4H6O, used (like tremorine) for the induction of experimental Parkinson's disease.
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the world > health and disease > healing > medicines or physic > medicines for specific purpose > [noun] > drugs used for research
promotor1947
tremorine1956
promoter1960
streptozotocin1960
oxotremorine1961
1961 A. K. Cho et al. in Biochem. & Biophysical Res. Communications 5 276 For purposes of rough measurement, a unit was defined as the dose per Kg. which on intravenous injection in mice gave this threshold effect. It proved to be equal to approximately 15 μg. of 2-oxotremorine base.
1970 R. Passmore & J. S. Robson Compan. Med. Stud. II. v. 560/2 Another method [of inducing symptoms of Parkinsonism] involves the use of the drug tremorine..or its active metabolite oxotremorine which induce tremor, rigidity, akinesia, analgesia and signs of peripheral cholinergic stimulation in many animal species.
1999 Proc. National Acad. Sci. U.S.A. 96 12223/2 Previous studies by Gomeza et al. established that oxotremorine-induced tremor in mouse is mediated by M2 muscarinic receptors.
This entry has been updated (OED Third Edition, March 2005; most recently modified version published online March 2022).
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n.1961