parthenoliden.

Brit.

/ˈpɑːθᵻnə(ʊ)lʌɪd/, U.S.

/ˈpɑrθənoʊˌlaɪd/

Origin: A borrowing from Latin, combined with English elements. Etymons: Latin parthenium , -o- connective, lactone n., -ide suffix.

Etymology: < parthen- (in scientific Latin parthenium, specific name of Tanacetum parthenium : see parthenium n.) + -o- connective + l- (in lactone n.) + -ide suffix.

Pharmacology.

A sesquiterpene lactone, C₁₅H₂₀O₃, with antibacterial and cytotoxic properties which is the active ingredient in preparations of the leaves and flowers of feverfew, Tanacetum parthenium, used as a herbal medicine for the prevention of migraine.

ΚΠ

1959 V. Herout et al. in Chem. & Industry 22 Aug. 1069/2 As a part of the study of sesquiterpenic lactones of the Compositae family, we isolated from Chrysanthemum parthenium (L.) Bernh. a substance..of..molecular formula C₁₅H₂₀O₃... As..the substance evidently was a new sesquiterpenic lactone; we suggest the name parthenolide for it.

1975 Ann. Missouri Bot. Garden 62 777 Michelia (Magnoliaceae) and two species of the Compositae, Ambrosia dumosa and A. confertiflora, produce the very same substance (parthenolide).

1992 Jrnl. Pharmacy & Pharmacol. 44 391 Authenticated Tanacetum parthenium grown in the UK contained a high level of parthenolide in leaves, flowering tops and seeds.

2002 Observer 3 Feb. (Life Suppl.) 45/3 Parthenolide appears to inhibit the release of inflammatory substances that may play a part in the blood-vessel changes typical in migraine.

This is a new entry (OED Third Edition, June 2005; most recently modified version published online March 2022).

单词	parthenolide
释义	parthenoliden. Brit. /ˈpɑːθᵻnə(ʊ)lʌɪd/, U.S. /ˈpɑrθənoʊˌlaɪd/ Origin: A borrowing from Latin, combined with English elements. Etymons: Latin parthenium , -o- connective, lactone n., -ide suffix. Etymology: < parthen- (in scientific Latin parthenium, specific name of Tanacetum parthenium : see parthenium n.) + -o- connective + l- (in lactone n.) + -ide suffix. Pharmacology. A sesquiterpene lactone, C₁₅H₂₀O₃, with antibacterial and cytotoxic properties which is the active ingredient in preparations of the leaves and flowers of feverfew, Tanacetum parthenium, used as a herbal medicine for the prevention of migraine. ΚΠ 1959 V. Herout et al. in Chem. & Industry 22 Aug. 1069/2 As a part of the study of sesquiterpenic lactones of the Compositae family, we isolated from Chrysanthemum parthenium (L.) Bernh. a substance..of..molecular formula C₁₅H₂₀O₃... As..the substance evidently was a new sesquiterpenic lactone; we suggest the name parthenolide for it. 1975 Ann. Missouri Bot. Garden 62 777 Michelia (Magnoliaceae) and two species of the Compositae, Ambrosia dumosa and A. confertiflora, produce the very same substance (parthenolide). 1992 Jrnl. Pharmacy & Pharmacol. 44 391 Authenticated Tanacetum parthenium grown in the UK contained a high level of parthenolide in leaves, flowering tops and seeds. 2002 Observer 3 Feb. (Life Suppl.) 45/3 Parthenolide appears to inhibit the release of inflammatory substances that may play a part in the blood-vessel changes typical in migraine. This is a new entry (OED Third Edition, June 2005; most recently modified version published online March 2022). < n.1959
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