pargylinen.
/ˈpɑːdʒᵻliːn/, U.S. /ˈpɑrdʒᵻlin/ Pharmacology.
A monoamine oxidase inhibitor synthesized from propargyl bromide and benzylmethylamine, (formerly) used to treat depression and hypertension; N-methyl-N-propargylbenzylamine, C6H5CH2N(CH3)CH2C≡CH.
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Neo-Synephrine1934
Priscol1938
phenylephrine1947
hexamethonium1949
Priscoline1949
methonium1950
hydralazine1952
phentolamine1953
methyldopa1954
pentolinium1954
mecamylamine1955
hydrochlorothiazide1958
pempidine1958
guanethidine1959
hydroflumethiazide1959
thiazide1959
pheniprazine1960
pargyline1961
vasodepressor1961
alpha blocker1965
clonidine1969
prazosin1970
timolol1973
1961 Current Therapeutic Res. 3 381 Pargyline hydrochloride appears to be a potent antihypertensive agent, the maximal effect of which is manifested slowly.
1962 Psychosomatics 3 310/2 We have found pargyline to be one of the most effective antidepressive agents clinically available.
1972 Materials & Technol. V. xxi. 792 Methyldopa and pargyline cause the replacement of noradrenaline by a weaker transmitter.
1977 Lancet 6 Aug. 275/1 Plasma-prolactin levels doubled in depressive patients treated with the monoamine-oxidase inhibitors, clorgyline and pargyline.
1989 Adverse Drug Reactions 8 34 These effects are consequences of monoamine oxidase inhibition, and some drugs of this group (e.g. pargyline) have been used as antihypertensive agents.
2004 Jrnl. Medicinal Chem. 47 1768/1 Crystallographic analysis of MAO B in complex with pargyline revealed the presence of two cavities inside the protein.
This entry has been updated (OED Third Edition, June 2005; most recently modified version published online March 2022).
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n.1961