Parkinsonn.
/ˈpɑːkɪns(ə)n/, U.S. /ˈpɑrkəns(ə)n/ Medicine.
I. Compounds.
1.
a. Parkinson's disease n. [after French maladie de Parkinson (J. M. Charcot 1876, in Progrès médical 2 Dec. 838/2)] a chronic, progressive neurological disorder of unknown aetiology, characterized especially by tremor, muscle rigidity, and difficulty in initiating movement, and associated with degeneration of dopaminergic neurons in certain parts of the brain. Also called paralysis agitans.
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the world > health and disease > ill health > a disease > disorders of internal organs > convulsive or paralytic disorders > [noun] > palsy or paralysis > Parkinson's disease or syndrome
paralysis agitans1817
Parkinson's disease1877
parkinsonism1923
Parkinson's syndrome1933
1877 G. Sigerson tr. D.-M. Bourneville in Charcot's Lect. Dis. Nerv. Syst. v. 144 This man, aged 50 years, was attacked by ‘Parkinson's disease’ in consequence of a strong emotion occasioned by the attempts of the Federalists, during the time of the Commune, to incorporate him in their battalions.
1888 W. R. Gowers Man. Dis. Nerv. Syst. II. v. 589 From the fact that it was first fully described by Parkinson in 1817, it has been called ‘Parkinson's disease’, but the name which he gave to it of ‘shaking palsy’ is both apt and adequate.
1909 Practitioner Feb. 290 In Parkinson's disease (paralysis agitans), the drug produced considerable decrease in all the cases.
1950 A. Huxley Let. 19 July (1969) 627 Poor Osbert [Sitwell] has got Parkinson's disease and has started to tremble.
1967 Canad. Med. Assoc. Jrnl. 97 52/1 This report is concerned only with the measurement of one aspect of Parkinson's disease—the loss of mobility at various joints.
1970 Daily Tel. 8 Sept. 3/3 General practitioners in the London postal area can now prescribe L-Dopa for patients with Parkinson's disease.
1995 J. Miller & M. Stacey Driving Instructor's Handbk. (ed. 8) ix. 286 Patients with Parkinson's Disease have difficulty in starting movement, including walking.
b. Parkinson's syndrome n. (also Parkinson syndrome) Parkinsonism; (also) (more fully idiopathic Parkinson's syndrome) Parkinson's disease.
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the world > health and disease > ill health > a disease > disorders of internal organs > convulsive or paralytic disorders > [noun] > palsy or paralysis > Parkinson's disease or syndrome
paralysis agitans1817
Parkinson's disease1877
parkinsonism1923
Parkinson's syndrome1933
1933 Jrnl. Nerv. & Mental Dis. 77 598 Of the 26 patients with the post-encephalitic Parkinson syndrome, the Hoffmann reflex was positive in 6 and the Babinski positive in 4.
1955 Sci. News Let. 20 Aug. 120/2 A drug of the antihistamine class has helped almost half of a group of patients suffering with the Parkinson syndrome, best known to the layman as shaking palsy.
1993 Central Television News Script (BNC) Hundreds of fans queued for hours to meet the man who became heavyweight champion of the world but in the process developed Parkinson's Syndrome.
2003 Jrnl. Neural Transmission 110 1289 Patients with idiopathic Parkinson's syndrome (IPS) show dysexecutive deficits which are not related to dementia.
2. attributive and in the genitive. Designating the symptoms and signs of Parkinson's disease, or a person suffering from Parkinson's disease.
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1967 Brain 90 893 Ekbom et al...noted that the H-reflex varied synchronously with parkinson tremor cycle.
1974 N.Y. Times 21 May 30/3 Drug benefits about 75% of Parkinson's patients.
1975 Jrnl. Gerontol. 30 301/1 Dysfluency or stuttering behaviour was observed in 20% of the Parkinson patients.
1989 Jrnl. Psychophysiol. 3 94/2 These results offer neurophysiological evidence of impaired preparation in the early stage of certain groups of Parkinson patients.
1991 N.Y. Times 8 Oct. c12/2 A similar kind of protein abnormality might underlie the changes seen in the brains of Alzheimer's and Parkinson's patients.
II. Simple uses.
3. In the genitive, used absol. Parkinson's disease.
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1950 W. Buchler Parkinson's Dis. ii. 12 At first Parkinson's made little, if any, difference in my appetite.
1972 N.Y. Times 5 May 9/1 This work is believed to be essential to understanding the cause of abnormal movements in diseases like Parkinson's.
1990 Sci. News 15 Sept. 174/1 Experiments..could simplify laboratory investigations of the molecular mechanisms underlying Parkinson's.
1999 BBC Vegetarian Good Food Apr. 81/2 The Towards Understanding, Learning and Improving Parkinson's (TULIP) campaign aims to educate people about Parkinson's,..and to dispel common misconceptions that Parkinson's is fatal and it's a condition that affects the elderly.
Derivatives
ˈParkinson-like adj.
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1956 Jrnl. Amer. Med. Assoc. 19 May 218/1 The neurotoxic reactions occurring with this drug [sc. chlorpromazine] can best be described as a ‘Parkinson-like syndrome’.
1987 J. Franklin Molecules of Mind (1988) viii. 101 Many patients developed a Parkinson-like slowing of bodily movements accompanied by awkward posture.
1997 R. Porter Greatest Benefit to Mankind xviii. 573 Scientists grasped that the new neuroleptic drugs, reserpine (also much used for lowering blood pressure) and the phenothiazines seemed to produce Parkinson-like symptoms by way of side-effects.
This entry has been updated (OED Third Edition, June 2005; most recently modified version published online March 2022).
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n.1877