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单词 perhexiline
释义

perhexilinen.

Brit. /pəːˈhɛksᵻliːn/, /pəːˈhɛksl̩iːn/, /pəːˈhɛksᵻlɪn/, /pəːˈhɛksl̩ɪn/, U.S. /pərˈhɛks(ə)lən/, /pərˈhɛksᵻlin/
Origin: Apparently formed within English, by derivation. Etymons: piperidine n., hexyl n., -ine suffix5.
Etymology: Apparently < -per- (in piperidine n.) + hexyl n. + -ine suffix5, with substitution of -i- for -y- in hexyl n.
Pharmacology.
A derivative of piperidine which is a vasodilator given (as the maleate) to relieve angina pectoris; 2-(2,2-dicyclohexylethyl)piperidine, C19H35N.
ΘΚΠ
the world > health and disease > healing > medicines or physic > medicines for specific purpose > preparations for treating specific parts > [noun] > for the heart > specific drugs
khellin1879
procainamide1950
pronethalol1963
propranolol1964
alprenolol1967
verapamil1967
oxprenolol1968
sotalol1968
perhexiline1969
practolol1969
beta-blocker1970
pindolol1971
acebutolol1972
mexiletine1973
atenolol1974
metoprolol1974
labetalol1975
propafenone1975
amrinone1977
1969 Current Therapeutic Res. 11 99 A clinical study was undertaken to explore the effectiveness of perhexiline in relief of angina pectoris.
1977 Lancet 30 July 260/1 The Committee on Safety of Medicines has circulated an adverse-reactions warning about perhexiline maleate (‘Pexid’).
1990 Cancer Res. 50 5558/2 Only perhexiline significantly enhances RTA-IT cytotoxicity in both cultured and fresh leukemic cells.
This entry has been updated (OED Third Edition, December 2005; most recently modified version published online March 2022).
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n.1969
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