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单词 pendrin
释义

pendrinn.

Brit. /ˈpɛndrɪn/, U.S. /ˈpɛndr(ə)n/
Origin: From a proper name, combined with an English element. Etymons: proper name Pendred , -in suffix1.
Etymology: < pendr- (in the name of Vaughan Pendred: see Pendred n.) + -in suffix1.
Biochemistry.
A membrane protein involved in anion (iodide and chloride) exchange, encoded by the Pendred syndrome gene.
ΚΠ
1997 Nature Genetics 17 411 The predicted protein, pendrin, is closely related to a number of known sulphate transporters.
1999 Proc. National Acad. Sci. U.S.A. 96 9727/2 The encoded protein, named pendrin, is closely related to numerous known proteins from a large taxonomic span.
2004 Endocrinology 145 4301 The present study further supports that pendrin is responsible for the iodide efflux in thyroid cells where intracellular iodide concentration is high and that the general function of pendrin in other tissues is to transport chloride through exchange with other anions.
This is a new entry (OED Third Edition, September 2005; most recently modified version published online March 2022).
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n.1997
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