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单词 phenytoin
释义

phenytoinn.

Brit. /ˈfɛnᵻtəʊɪn/, U.S. /ˈfɛnəˌtoʊən/
Origin: Formed within English, by compounding. Etymons: phenyl n., hydantoïn n. at hydantoic adj. Derivatives.
Etymology: < pheny- (in phenyl n.) + -toin (in hydantoïn n. at hydantoic adj. Derivatives).
Pharmacology.
An anticonvulsant drug; (more fully phenytoin sodium) the sodium salt of this.Chemical name: 5,5-diphenylhydantoin, C15H12N2O2. A proprietary name for this drug in the United States is Dilantin n.
ΘΚΠ
the world > health and disease > healing > medicines or physic > medicines for specific purpose > sedatives, antispasmodics, etc. > [noun] > antispasmodic or anticonvulsant > specific substances or preparations
Dilantin1938
phenytoin1942
Artane1948
Mysoline1949
mephenesin1952
troxidone1952
primidone1953
acetazolamide1954
orphenadrine1957
tetrabenazine1958
ethosuximide1960
methsuximide1965
clonazepam1970
valproic1972
valproate1974
1942 Jrnl. Amer. Med. Assoc. 4 Apr. 1209/2 While phenytoin sodium (sodium diphenyl hydrantoinate, or dilantin sodium) was effective in protecting animals from electrically induced convulsions it produced little sedative effect.
1952 A. H. Douthwaite Hale-White's Mat. Med. (ed. 29) 193 When grand mal and petit mal occur in the same patient phenobarbitone and troxidone should be used together: phenytoin must not be employed.
1968 Brain 91 202 In 1956, Girdwood and Lenman first drew attention to certain structural similarities between phenobarbitone, phenytoin, primidone and folic acid.
1995 Family Health Spring 17/3 Phenytoin (Dilantin), Phenobarbital, and Valproic Acid are drugs used to control seizures in epilepsy and are all Category D.
This entry has been updated (OED Third Edition, December 2005; most recently modified version published online March 2022).
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n.1942
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