pharmacodynamicadj.

1846 Brit. Jrnl. Homœopathy 4 139 Convulsions are seldom absent in poisonings by Arsenic; but as they are generally first observed a short time before death, it is easy to comprehend that they are of no great pharmacodynamic value.

1890 Cent. Dict. Pharmacodynamic, pertaining to the action of drugs on living organisms.

1906 Jrnl. Infectious Dis. 3 572 (heading) Pharmacodynamic action due to ions.

1926 Amer. Mercury Mar. 268/1 I magnanimously maintain silence before tea and coffee, merely pointing out in passing that both have easily-measurable pharmacodynamic actions.

1967 Canad. Med. Assoc. Jrnl. 15 July 120/1 As mentioned above, the distinction between pharmacodynamic and placebo effects requires that the latter be distributed as evenly as possible between subgroups.

1994 Maturity July–Aug. 11/1 The second [main type of drug interaction] is pharmacodynamic, or how your body responds to a drug.

1858 Eclectic Med. Jrnl. Mar. 124 Chemical Remedies (viz., pharmaceutic) can be classified in two different ways—either physico-chemically, or pharmaco-dynamically.

1929 H. H. Mitchell & T. S. Hamilton Biochem. Amino Acids vii. 363 It is a fact of great significance that histidine, a substance entirely indifferent pharmacodynamically, should be transformable by simple decarboxylation into such an active substance as histamine.

2003 Guardian 23 Sept. ii. 8/1 I mean, pharmacodynamically speaking,..I can understand how a slow afternoon spent drinking warm, flat English beer might give a different plasma-concentration profile over time than the sudden, practically intravenous blast of alcohol from champagne.