physostigminen.

Brit.

/ˌfʌɪsəʊˈstɪɡmiːn/, U.S.

/ˌfaɪsoʊˈstɪɡˌmin/

Forms: 1800s– physostigmin, 1800s– physostigmine.

Origin: A borrowing from German. Etymon: German Physostigmin.

Etymology: < German Physostigmin (J. Jobst & O. Hesse 1864, in Ann. d. Chem. u. Pharm. 129 118) < scientific Latin Physostigma (see Physostigma n.) + German -in -ine suffix⁵.

Chemistry and Pharmacology.

A tricyclic alkaloid, C₁₅H₂₁N₃O₂, originally found in the calabar bean (the seed of Physostigma venenosum), which is used medically as a cholinesterase inhibitor, chiefly in the treatment of glaucoma. Also called eserine.

ΘΚΠ

the world > matter > chemistry > organic chemistry > alkaloids > [noun] > miscellaneous other

daturia1820

piperine1820

opiane1824

daturine1825

aconitine1826

serpentaria1829

solania1830

fagine1833

aconitia1834

buxine1836

porphyroxine1838

surinamine1838

staphisaïne1842

lobeline1844

passiflorine1846

aricine1847

arnicine1847

harmaline1847

papaverine1848

pelosine1851

colchicine1853

helleborin1853

parvoline1855

punicin1855

aconella1864

fluavil1864

physostigmine1864

herapathite1865

ratanhine1868

sipeerine1868

staphisagrine1868

codamine1870

rhoeagenine1870

aconelline1871

helleborein1871

helleboresin1871

helleboretin1871

meconidine1871

napelline1871

hyoscine1872

porphyrine1872

septicine1872

paytine1873

reducine1875

hydrastine1876

pelosia1876

veratralbia1876

aconine1878

piturine1878

paytamine1879

skatol1879

tropidine1879

pelletierine1881

thalictrine1881

tetano-cannabine1883

cupreine1884

scopoleine1885

trigonelline1886

hydrastinine1887

jaborine1887

scopoline1887

apomorphine1888

imperialine1888

tetanine1888

tongine1890

guvacine1891

veratralbine1891

veratroidine1891

scopolamine1892

corybulbine1893

corycavine1893

corytuberine1893

septentrionaline1894

theophylline1894

pellotine1895

yohimbenine1897

ibogaine1902

scopine1923

nornicotine1927

norephedrine1929

pyrrolizidine alkaloid1951

psilocin1958

psilocybin1958

sodide1977

the world > health and disease > healing > medicines or physic > medical preparations of specific origin > medicine composed of a plant > [noun] > alkaloids

belladonna1788

bebeerine1851

sparteine1851

physostigmine1864

bebeeria1874

pilocarpine1875

hydrastine1876

atropine1877

eserine1879

homatropine1880

ergocryptine1944

1864 Chem. News 5 Mar. 109/1 The physiological properties of the Calabar bean have been well studied in this country, but the authors above named are..the first who have isolated the alkaloid to which it owes its activity, and to which they have given the name Physostigmine.

1896 T. C. Allbutt et al. Syst. Med. I. 228 It is in this way that strychnine and physostigmine respectively stimulate and depress the spinal cord.

1907 J. H. Parsons Dis. Eye iv. 74 Eserin or physostigmin, the most powerful miotic we possess, acts by stimulating the third nerve endings in the sphincter and in the ciliary muscle.

1970 Nature 4 Apr. 21/2 Drugs which..increase the concentration [in the brain] of acetylcholine (for example, physostigmine) exacerbate Parkinsonism.

2003 New Scientist 28 June 49/1 The usual victims of this type of poisoning were children who had swallowed the berries of deadly nightshade, and many were saved by swift treatment with physostigmine.

This entry has been updated (OED Third Edition, March 2006; most recently modified version published online March 2022).

单词	physostigmine
释义	physostigminen. Brit. /ˌfʌɪsəʊˈstɪɡmiːn/, U.S. /ˌfaɪsoʊˈstɪɡˌmin/ Forms: 1800s– physostigmin, 1800s– physostigmine. Origin: A borrowing from German. Etymon: German Physostigmin. Etymology: < German Physostigmin (J. Jobst & O. Hesse 1864, in Ann. d. Chem. u. Pharm. 129 118) < scientific Latin Physostigma (see Physostigma n.) + German -in -ine suffix⁵. Chemistry and Pharmacology. A tricyclic alkaloid, C₁₅H₂₁N₃O₂, originally found in the calabar bean (the seed of Physostigma venenosum), which is used medically as a cholinesterase inhibitor, chiefly in the treatment of glaucoma. Also called eserine. ΘΚΠ the world > matter > chemistry > organic chemistry > alkaloids > [noun] > miscellaneous other daturia1820 piperine1820 opiane1824 daturine1825 aconitine1826 serpentaria1829 solania1830 fagine1833 aconitia1834 buxine1836 porphyroxine1838 surinamine1838 staphisaïne1842 lobeline1844 passiflorine1846 aricine1847 arnicine1847 harmaline1847 papaverine1848 pelosine1851 colchicine1853 helleborin1853 parvoline1855 punicin1855 aconella1864 fluavil1864 physostigmine1864 herapathite1865 ratanhine1868 sipeerine1868 staphisagrine1868 codamine1870 rhoeagenine1870 aconelline1871 helleborein1871 helleboresin1871 helleboretin1871 meconidine1871 napelline1871 hyoscine1872 porphyrine1872 septicine1872 paytine1873 reducine1875 hydrastine1876 pelosia1876 veratralbia1876 aconine1878 piturine1878 paytamine1879 skatol1879 tropidine1879 pelletierine1881 thalictrine1881 tetano-cannabine1883 cupreine1884 scopoleine1885 trigonelline1886 hydrastinine1887 jaborine1887 scopoline1887 apomorphine1888 imperialine1888 tetanine1888 tongine1890 guvacine1891 veratralbine1891 veratroidine1891 scopolamine1892 corybulbine1893 corycavine1893 corytuberine1893 septentrionaline1894 theophylline1894 pellotine1895 yohimbenine1897 ibogaine1902 scopine1923 nornicotine1927 norephedrine1929 pyrrolizidine alkaloid1951 psilocin1958 psilocybin1958 sodide1977 the world > health and disease > healing > medicines or physic > medical preparations of specific origin > medicine composed of a plant > [noun] > alkaloids belladonna1788 bebeerine1851 sparteine1851 physostigmine1864 bebeeria1874 pilocarpine1875 hydrastine1876 atropine1877 eserine1879 homatropine1880 ergocryptine1944 1864 Chem. News 5 Mar. 109/1 The physiological properties of the Calabar bean have been well studied in this country, but the authors above named are..the first who have isolated the alkaloid to which it owes its activity, and to which they have given the name Physostigmine. 1896 T. C. Allbutt et al. Syst. Med. I. 228 It is in this way that strychnine and physostigmine respectively stimulate and depress the spinal cord. 1907 J. H. Parsons Dis. Eye iv. 74 Eserin or physostigmin, the most powerful miotic we possess, acts by stimulating the third nerve endings in the sphincter and in the ciliary muscle. 1970 Nature 4 Apr. 21/2 Drugs which..increase the concentration [in the brain] of acetylcholine (for example, physostigmine) exacerbate Parkinsonism. 2003 New Scientist 28 June 49/1 The usual victims of this type of poisoning were children who had swallowed the berries of deadly nightshade, and many were saved by swift treatment with physostigmine. This entry has been updated (OED Third Edition, March 2006; most recently modified version published online March 2022). < n.1864
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