phthalylsulphathiazolephthalylsulfathiazolen.

Brit.

/ˌ(f)θalʌɪlˌsʌlfəˈθʌɪəzəʊl/,

/ˌ(f)θalɪlˌsʌlfəˈθʌɪəzəʊl/, U.S.

/ˈˌθæləlˌsəlfəˈθaɪəˌzoʊl/

Forms: 1900s– phthalylsulphathiazole, 1900s– phthalylsulfathiazole (U.S.).

Origin: Formed within English, by compounding. Etymons: phthalyl n., sulpha- comb. form, thiazole n. at thio- comb. form 1

Etymology: < phthalyl n. + sulpha- comb. form + thiazole n. at thio- comb. form 1.

Pharmacology.

An antibiotic of the sulphonamide class which is poorly absorbed from the gastrointestinal tract and is used chiefly to reduce the bacterial flora of the bowel before surgery.Chemical name: 4′-(2-thiazolylsulphamyl)phthalanilic acid; HOOC·C₆H₄·CONH·C₆H₄·SO₂NH·C₃H₂NS.

ΘΚΠ

the world > health and disease > healing > medicines or physic > medicines for specific purpose > substances acting on bacteria > [noun] > bacteriostatic > sulphonamide > specific

Prontosil1935

Prontosil soluble1936

Albucid1938

Prontosil red1938

sulphapyridine1939

sulphathiazole1939

sulphadiazine1940

succinylsulphathiazole1941

sulphacetamide1941

sulphaguanidine1941

sulphamethazine1942

phthalylsulphathiazole1943

sulfamerazine1943

Sulphamezathine1943

Sulphatriad1948

sulphadimidine1950

sulphamethizole1952

sulphisoxazole1952

sulphamethoxypyridazine1956

sulphamethoxazole1960

sulphafurazole1961

sulphasalazine-

1943 Poth & Ross in Federation Proc. (Federation Amer. Soc. Exper. Biol.) 2 89/2 An extension of the studies on acylated sulfonamides as intestinal antiseptics..has uncovered another effective derivative of this series of drugs, phthalylsulfathiazole.

1961 M. Hynes Med. Bacteriol. (ed. 7) x. 138 Inabsorbable compounds (e.g., phthalyl-sulphathiazole) are available for oral treatment of intestinal infections.

1977 Proc. Royal Soc. Med. 70 482/1 The preliminary results of this study have shown that a combination of oral phthalylsulphathiazole and metronidazole for preparation of the bowel for surgery reduces the incidence of postoperative infection compared with phthalylsulphathiazole alone.

1996 Amer. Jrnl. Nat. Med. (Nexis) 31 May 14 The metabolism of sulfasalazine, chloramphenicol palmitate, and phthalylsulfathiazole is affected by L[actobacillus] acidophilus.

This entry has been updated (OED Third Edition, March 2006; most recently modified version published online March 2022).

单词	phthalylsulphathiazole
释义	phthalylsulphathiazolephthalylsulfathiazolen. Brit. /ˌ(f)θalʌɪlˌsʌlfəˈθʌɪəzəʊl/, /ˌ(f)θalɪlˌsʌlfəˈθʌɪəzəʊl/, U.S. /ˈˌθæləlˌsəlfəˈθaɪəˌzoʊl/ Forms: 1900s– phthalylsulphathiazole, 1900s– phthalylsulfathiazole (U.S.). Origin: Formed within English, by compounding. Etymons: phthalyl n., sulpha- comb. form, thiazole n. at thio- comb. form 1 Etymology: < phthalyl n. + sulpha- comb. form + thiazole n. at thio- comb. form 1. Pharmacology. An antibiotic of the sulphonamide class which is poorly absorbed from the gastrointestinal tract and is used chiefly to reduce the bacterial flora of the bowel before surgery.Chemical name: 4′-(2-thiazolylsulphamyl)phthalanilic acid; HOOC·C₆H₄·CONH·C₆H₄·SO₂NH·C₃H₂NS. ΘΚΠ the world > health and disease > healing > medicines or physic > medicines for specific purpose > substances acting on bacteria > [noun] > bacteriostatic > sulphonamide > specific Prontosil1935 Prontosil soluble1936 Albucid1938 Prontosil red1938 sulphapyridine1939 sulphathiazole1939 sulphadiazine1940 succinylsulphathiazole1941 sulphacetamide1941 sulphaguanidine1941 sulphamethazine1942 phthalylsulphathiazole1943 sulfamerazine1943 Sulphamezathine1943 Sulphatriad1948 sulphadimidine1950 sulphamethizole1952 sulphisoxazole1952 sulphamethoxypyridazine1956 sulphamethoxazole1960 sulphafurazole1961 sulphasalazine- 1943 Poth & Ross in Federation Proc. (Federation Amer. Soc. Exper. Biol.) 2 89/2 An extension of the studies on acylated sulfonamides as intestinal antiseptics..has uncovered another effective derivative of this series of drugs, phthalylsulfathiazole. 1961 M. Hynes Med. Bacteriol. (ed. 7) x. 138 Inabsorbable compounds (e.g., phthalyl-sulphathiazole) are available for oral treatment of intestinal infections. 1977 Proc. Royal Soc. Med. 70 482/1 The preliminary results of this study have shown that a combination of oral phthalylsulphathiazole and metronidazole for preparation of the bowel for surgery reduces the incidence of postoperative infection compared with phthalylsulphathiazole alone. 1996 Amer. Jrnl. Nat. Med. (Nexis) 31 May 14 The metabolism of sulfasalazine, chloramphenicol palmitate, and phthalylsulfathiazole is affected by L[actobacillus] acidophilus. This entry has been updated (OED Third Edition, March 2006; most recently modified version published online March 2022). < n.1943
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