pleiotropismn.
/ˌplʌɪəˈtrəʊpɪz(ə)m/, U.S. /ˌplaɪəˈtroʊˌpɪz(ə)m/ Genetics.
= pleiotropy n.
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the world > life > biology > biological processes > genetic activity > genetic constitution > [noun] > phenotype > phenotypic effects
potency1916
pleiotropism1927
position effect1930
penetrance1934
pleiotropy1938
complementation1958
1927 Zeitschr. f. Induktive Abstammungs- u. Vererbungslehre 43 331 Plate..proposed the term ‘pleiotrop’... Some of the highest authorities in the field of genetics have come to the conclusion that the pleiotropism of the genes is not an exception but rather the general rule.
1970 T. Dobzhansky Genetics Evol. Process vii. 210 Correlated responses due to pleiotropisms (physiological correlations) may make it impossible to endow a breed..with combinations of characteristics that would be desirable to man.
1993 Jrnl. Amer. Med. Assoc. 17 Nov. 2354/3 Pleiotropism—multiple clinical manifestations of a single mutant gene—is important, among other reasons, because one manifestation may be an important clue to serious internal disease, eg. the subluxation of the lenses in Marfan syndrome and in homocystinuria.
This entry has been updated (OED Third Edition, September 2006; most recently modified version published online March 2022).
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n.1927