polyclonaladj.n.

1914 W. E. Agar in Philos. Trans. (Royal Soc.) B. 205 422 When a population..is composed of a number of clones each descended from an original ancestor not asexually connected with the original ancestors of the other clones, the population may be called polyclonal.

1961 Harvey Lect. 56 221 He had a broad-banded, polyclonal γ-globulin with a rich serological picture.

1984 M. J. Taussig Processes in Pathol. & Microbiol. (ed. 2) iv. 442 It is a polyclonal activator of B cells, meaning that as well as dividing, endotoxin-stimulated B cells mature into antibody-secreting cells and produce IgM.

1991 Lancet 2 Mar. 507/2 This process would be analogous to that leading to endemic Burkitt's lymphoma, in which polyclonal lymphoid expansion due to malaria is also thought to be part of a multistep process.

1994 Sci. Amer. Nov. 30/2 If all strains are equally virulent, and epidemics occur solely because of changes in host and environmental factors, then epidemics would tend to be polyclonal because each strain would be equally likely to cause disease.

1984 FEBS Lett. 175 334/1 One peptide..shows marked reactivity towards both monoclonals and polyclonals.

1992 Gene 110 65 The fusion proteins produced by the clones were then used as an affinity immunoadsorbant to select monospecific polyclonals.

2005 Res. Vet. Sci. 79 31/1 Three of the antibodies were mouse monoclonals, the other two, R524 and R505, were rabbit polyclonals.

1972 Proc. National Acad. Sci. U.S.A. 69 229/2 The isoelectric spectra of the biosynthetically homogeneous murine anti-Dup antibody and of polydispersed (polyclonal) rabbit antibody..are illustrated.]

1973 European Jrnl. Immunol. 3 608/2 B cell mitogens..are known to activate B cells directly into increased DNA synthesis and polyclonal antibody synthesis.

1992 Farmers Guardian 7 Aug. 115 Calf health [was] improved by the addition of Betaclone, which supplies bovine polyclonal antibodies to boost the calf's immune system, suppress pathogens and improve desirable digestive microbes.

2004 Jrnl. Pharmaceut. Sci. 93 2645 The U.S. Food and Drug Administration (FDA) has approved several polyclonal antibody preparations and at least 18 monoclonal antibody preparations.