acriflavinen.
/ˌakrᵻˈfleɪvɪn/, /ˌakrᵻˈfleɪviːn/, U.S. /ˌækrəˈfleɪvin/ Pharmacology and Biochemistry.
An orange antibiotic and antiseptic compound used esp. to treat minor wounds and also in microscopy for the identification of nucleic acids and polysaccharides. Acriflavine consists of 3,6-diamino-10-methyl-acridinium chloride (C14H14N3Cl), usually also with some 3,6-acridinediamine (C13H11N3). An earlier name for acriflavine was trypaflavine n.
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the world > health and disease > healing > medicines or physic > medicines for specific purpose > antiseptic > [noun] > substances for dressing wounds or burns
iodoform1838
gentian violet1876
camphoid1896
orthoform1897
thioform1899
thioresorcin1899
thiuret1899
traumatol1899
trypaflavine1913
bipp1916
acriflavine1917
propamidine1941
1917 Brit. Med. Jrnl. 9 June 769/2 The Medical Research Committee have proposed for important technical reasons that the substance shall be officially called ‘Acriflavine’ in this country.
1943 Endeavour Apr. 41/2 It had been shown that acriflavine or proflavine need not kill trout ova which they nevertheless sterilize.
1975 Methods Enzymol. 40 24 Recently, two well established methods have been described in detail for the demonstration of the nucleic acids at the EM [= electron microscopy] level... The first one is based on the specificity of acriflavine for nucleic acids.
1986 Mycologia 78 901/2 This is the first report of the use of acriflavin as a fluorochrome for meiotic chromosomes in fungi.
2008 M. Goetz et al. in R. Kiesslich & P. R. Galle Atlas Endomicrosc. iv. 31/1 Acriflavine hydrochloride stains the nuclei and also helps visualise the cytoplasm to a lesser extent.
This entry has been updated (OED Third Edition, December 2011; most recently modified version published online December 2021).
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n.1917