pregnenolonen.

Brit.

/prɛɡˈniːnələʊn/, U.S.

/prɛɡˈninəˌloʊn/

Origin: Formed within English, by derivation; modelled on a German lexical item. Etymons: pregnane n., -ene comb. form, -ol suffix, -one suffix.

Etymology: < pregn- (in pregnane n.) + -ene comb. form + -ol suffix + -one suffix, after German Pregnenolon (A. Butenandt & U. Westphal 1934, in Berichte der Deutsch. Chem. Ges. 67 2085).

Biochemistry and Medicine.

A naturally occurring neuroactive steroid which is a precursor of progesterone and other steroid hormones and has been used an anti-inflammatory agent; 3β-hydroxypregn-5-en-20-one, C₂₁H₃₂O₂.

ΘΚΠ

the world > health and disease > healing > medicines or physic > medical preparations of specific origin > hormones and substances with same effect > [noun]

epinephrine1899

pituitrin1909

oxytocin1927

Pitocin1929

Pitressin1929

progestin1930

progesterone1935

methyltestosterone1936

pregnenolone1936

hexœstrol1939

stilboestrol1939

hydroxyprogesterone1941

progestogen1941

Premarin1942

hydroxycorticosterone1943

gestagen1948

hydrocortisone1951

cortisol1953

fluorohydrocortisone1954

isophane1954

prednisolone1955

prednisone1955

norethisterone1956

norethynodrel1957

dexamethasone1958

fludrocortisone1958

norethindrone1960

antidiuretic hormone1961

medroxyprogesterone1962

Pergonal1963

mesterolone1965

norgestrel1966

quinestrol1966

pancuronium1967

pentagastrin1967

levonorgestrel1977

the world > health and disease > healing > medicines or physic > medicines for specific purpose > preparations treating or preventing specific ailments > [noun] > for arthritis, rheumatism, or gout > synthetic or biological

pregnenolone1936

methylprednisolone1957

nabumetone1980

1936 Chem. Abstr. 30 3036 Similar mixts. of III and I or III and pregnenolone (IV) met with in the prepn. of the hormone from stigmasterol can be sepd. in the same manner.

1955 Jrnl. Amer. Med. Assoc. 21 May 166/1 All the patients had received, at one time or another, gold salts, pregnenolone, antibiotics,..[etc.] that produced, at the most, only palliative relief.

1964 E. J. W. Barrington Hormones & Evol. ii. 54 Cholesterol is thought to be transformed into progesterone, through the intermediary pregnenolone, by partial degradation of its side chain.

1995 N.Y. Times 27 June c3/2 It has long been known that progesterone, and its precursor compound, pregnenolone, are synthesized in the central nervous system.

This entry has been updated (OED Third Edition, March 2007; most recently modified version published online March 2022).

单词	pregnenolone
释义	pregnenolonen. Brit. /prɛɡˈniːnələʊn/, U.S. /prɛɡˈninəˌloʊn/ Origin: Formed within English, by derivation; modelled on a German lexical item. Etymons: pregnane n., -ene comb. form, -ol suffix, -one suffix. Etymology: < pregn- (in pregnane n.) + -ene comb. form + -ol suffix + -one suffix, after German Pregnenolon (A. Butenandt & U. Westphal 1934, in Berichte der Deutsch. Chem. Ges. 67 2085). Biochemistry and Medicine. A naturally occurring neuroactive steroid which is a precursor of progesterone and other steroid hormones and has been used an anti-inflammatory agent; 3β-hydroxypregn-5-en-20-one, C₂₁H₃₂O₂. ΘΚΠ the world > health and disease > healing > medicines or physic > medical preparations of specific origin > hormones and substances with same effect > [noun] epinephrine1899 pituitrin1909 oxytocin1927 Pitocin1929 Pitressin1929 progestin1930 progesterone1935 methyltestosterone1936 pregnenolone1936 hexœstrol1939 stilboestrol1939 hydroxyprogesterone1941 progestogen1941 Premarin1942 hydroxycorticosterone1943 gestagen1948 hydrocortisone1951 cortisol1953 fluorohydrocortisone1954 isophane1954 prednisolone1955 prednisone1955 norethisterone1956 norethynodrel1957 dexamethasone1958 fludrocortisone1958 norethindrone1960 antidiuretic hormone1961 medroxyprogesterone1962 Pergonal1963 mesterolone1965 norgestrel1966 quinestrol1966 pancuronium1967 pentagastrin1967 levonorgestrel1977 the world > health and disease > healing > medicines or physic > medicines for specific purpose > preparations treating or preventing specific ailments > [noun] > for arthritis, rheumatism, or gout > synthetic or biological pregnenolone1936 methylprednisolone1957 nabumetone1980 1936 Chem. Abstr. 30 3036 Similar mixts. of III and I or III and pregnenolone (IV) met with in the prepn. of the hormone from stigmasterol can be sepd. in the same manner. 1955 Jrnl. Amer. Med. Assoc. 21 May 166/1 All the patients had received, at one time or another, gold salts, pregnenolone, antibiotics,..[etc.] that produced, at the most, only palliative relief. 1964 E. J. W. Barrington Hormones & Evol. ii. 54 Cholesterol is thought to be transformed into progesterone, through the intermediary pregnenolone, by partial degradation of its side chain. 1995 N.Y. Times 27 June c3/2 It has long been known that progesterone, and its precursor compound, pregnenolone, are synthesized in the central nervous system. This entry has been updated (OED Third Edition, March 2007; most recently modified version published online March 2022). < n.1936
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