properdinn.
/prəʊˈpəːdɪn/, U.S. /proʊˈpərd(ə)n/ Physiology.
Any of a group of proteins found in the blood and involved in the alternative pathway of complement activation.
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the world > life > biology > substance > process stimulators or inhibitors > antibody > [noun] > types of
Russell body1892
precipitin1900
nephrotoxin1902
hepatotoxin1903
opsonin1903
autoantibody1905
concanavalin1917
isoantibody1919
reagin1925
immune globulin1934
macroglobulin1952
immunoglobulin1953
properdin1954
LATS1961
alloantibody1964
xenoantibody1974
monoclonal1980
abzyme1986
1954 L. Pillemer et al. in Science 20 Aug. 279/1 This protein, tentatively named properdin.., acts only in conjunction with complement and Mg+ +... Properdin is a normal serum constituent and differs from antibody in many respects, particularly in its lack of specificity and in its exact requirements. [Note] Hans Hirschmann..suggested this name.
1975 Spragg & Gigli in A. Mathieu & B. D. Kahan Immunol. Aspects Anesthetic & Surg. Pract. vi. 116 Properdin has been highly purified as a distinct protein with a molecular weight of 223,000 daltons.
1988 A. M. Silverstein Hist. Immunol. ix. 243 Pillemer described a new substance, properdin , which was held to be a significant contributor to natural (nonantibody) immunity.
2002 Proc. National Acad. Sci. U.S.A. 99 1498/2 Properdin..is a C3-convertase stabilizer that functions in the activation of the alternative complement pathway.
This entry has been updated (OED Third Edition, June 2007; most recently modified version published online March 2022).
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n.1954