> as lemmas

1916 E. A. Schäfer Endocrine Organs xvii. 128 Provisionally, it will be convenient to refer to this hypothetical autacoid as insuline. It must, however, be stated that it has yet to be determined whether the active substance is present as such in the pancreas or whether it exists there as pro-insuline, which becomes elsewhere converted into the active autacoid.

1967 D. F. Steiner et al. in Science 26 Apr. 700/2 The labeling data reported here support our earlier interpretation that component b is a precursor in the biosynthesis of insulin. It might be less cumbersome, therefore, to designate this material ‘proinsulin’.

1990 Sci. Amer. July 49 (caption) As the beta cells become ever more damaged, substances normally sequestered within them such as proinsulin, begin to appear at the surface of the cell.