proteasen.

Brit.

/ˈprəʊtɪeɪz/, U.S.

/ˈproʊdiˌeɪz/,

/ˈproʊdiˌeɪs/

Origin: Formed within English, by derivation. Etymons: protein n., -ase suffix.

Etymology: < prote- (in protein n.) + -ase suffix. Compare French protéase (1900). Compare slightly later proteinase n.

Biochemistry.

An enzyme that degrades proteins or polypeptides by hydrolysing peptide bonds; a peptidase. Cf. proteinase n.

ΘΚΠ

the world > life > biology > substance > process stimulators or inhibitors > other stimulators or inhibitors > [noun]

styptica1400

carrier1844

luciferase1888

luciferin1888

urease1892

peroxidase1899

protease1903

renin1903

phenolase1907

proteinase1907

phytase1908

lecithinase1910

uricase1910

phosphatase1912

prunase1912

phenoloxidase1913

oxytocin1927

phosphomonoesterase1932

androgen1936

phosphorylase1939

slow reacting substance1939

phospholipase1945

plasmin1945

bradykinin1949

nitroreductase1953

cytostatic1964

oncogen1967

autoinducer1968

1903 Ann. Bot. 17 237 There is at present evidence that enzymes which digest proteids (proteases) occur..in certain lowly Algae, in some fungi, and in various Phanerogams.

1923 Jrnl. Chem. Soc. 124 i. 496 The proteases can be provisionally classified as follows. A. True proteases which break down protein to the peptide stage... B. Peptidases or ereptases which only split peptides or peptones.

1973 E. Zeffren & P. L. Hall Study of Enzyme Mechanisms ix. 168 Chymotrypsin is one of several proteolytic enzymes or proteases which function collectively in the mammalian small intestine.

1995 McGill Jrnl. Med. Spring 75/1 Some allergens are proteases..that may directly stimulate IL-4 production by basophils or mast cells.

Compounds

protease inhibitor n. a substance that inhibits the action of proteases; spec. any of a class of drugs used in the treatment of HIV infection, which suppress viral replication by inhibiting the protease necessary for the production of viral structural and functional proteins.

ΚΠ

1943 Science 9 Apr. 321/2 We can leave to the immunologists the problems of ‘foreign’ protein cleavage but suggest that they look for quantitative changes in normal protease-inhibitors.

1976 Path. Ann. 11 380 This may be related in part to the presence of protease inhibitors in connective tissues.

1996 Time 30 Dec. 54/1 Early this summer aids patients taking therapeutic ‘cocktails’ that combine protease inhibitors with other antiviral drugs began experiencing remarkable recoveries.

protease-resistant protein n. a protein resistant to the action of proteases; esp. (in full protease-resistant prion protein) a prion protein of this kind; abbreviated PrP.

ΚΠ

1980 Proc. National Acad. Sci. U.S.A. 77 3225 [Keyword] Protease-resistant protein.

1984 Jrnl. Bacteriol. 160 989 The protease-resistant proteins associated with the peptidoglycan (PG) of the phase I small-cell variant C. burnetii were..totally released by 1 N NaOH hydrolysis at 23°C.

1990 Lancet 26 May 1275/1 Brain from BSE-affected cattle contains scrapie-associated fibrils and the protease-resistant protein (PrP_27–30), which are laboratory markers for the subacute spongiform encephalopathies.

1999 Farmers Weekly (Nexis) 9 July 88 We have recently succeeded in producing a protease resistant prion protein (considered to be the central feature of TSE) after exposing recombinant prion protein to manganese on the laboratory bench.

This entry has been updated (OED Third Edition, June 2007; most recently modified version published online March 2022).

单词	protease
释义	proteasen. Brit. /ˈprəʊtɪeɪz/, U.S. /ˈproʊdiˌeɪz/, /ˈproʊdiˌeɪs/ Origin: Formed within English, by derivation. Etymons: protein n., -ase suffix. Etymology: < prote- (in protein n.) + -ase suffix. Compare French protéase (1900). Compare slightly later proteinase n. Biochemistry. An enzyme that degrades proteins or polypeptides by hydrolysing peptide bonds; a peptidase. Cf. proteinase n. ΘΚΠ the world > life > biology > substance > process stimulators or inhibitors > other stimulators or inhibitors > [noun] styptica1400 carrier1844 luciferase1888 luciferin1888 urease1892 peroxidase1899 protease1903 renin1903 phenolase1907 proteinase1907 phytase1908 lecithinase1910 uricase1910 phosphatase1912 prunase1912 phenoloxidase1913 oxytocin1927 phosphomonoesterase1932 androgen1936 phosphorylase1939 slow reacting substance1939 phospholipase1945 plasmin1945 bradykinin1949 nitroreductase1953 cytostatic1964 oncogen1967 autoinducer1968 1903 Ann. Bot. 17 237 There is at present evidence that enzymes which digest proteids (proteases) occur..in certain lowly Algae, in some fungi, and in various Phanerogams. 1923 Jrnl. Chem. Soc. 124 i. 496 The proteases can be provisionally classified as follows. A. True proteases which break down protein to the peptide stage... B. Peptidases or ereptases which only split peptides or peptones. 1973 E. Zeffren & P. L. Hall Study of Enzyme Mechanisms ix. 168 Chymotrypsin is one of several proteolytic enzymes or proteases which function collectively in the mammalian small intestine. 1995 McGill Jrnl. Med. Spring 75/1 Some allergens are proteases..that may directly stimulate IL-4 production by basophils or mast cells. Compounds protease inhibitor n. a substance that inhibits the action of proteases; spec. any of a class of drugs used in the treatment of HIV infection, which suppress viral replication by inhibiting the protease necessary for the production of viral structural and functional proteins. ΚΠ 1943 Science 9 Apr. 321/2 We can leave to the immunologists the problems of ‘foreign’ protein cleavage but suggest that they look for quantitative changes in normal protease-inhibitors. 1976 Path. Ann. 11 380 This may be related in part to the presence of protease inhibitors in connective tissues. 1996 Time 30 Dec. 54/1 Early this summer aids patients taking therapeutic ‘cocktails’ that combine protease inhibitors with other antiviral drugs began experiencing remarkable recoveries. protease-resistant protein n. a protein resistant to the action of proteases; esp. (in full protease-resistant prion protein) a prion protein of this kind; abbreviated PrP. ΚΠ 1980 Proc. National Acad. Sci. U.S.A. 77 3225 [Keyword] Protease-resistant protein. 1984 Jrnl. Bacteriol. 160 989 The protease-resistant proteins associated with the peptidoglycan (PG) of the phase I small-cell variant C. burnetii were..totally released by 1 N NaOH hydrolysis at 23°C. 1990 Lancet 26 May 1275/1 Brain from BSE-affected cattle contains scrapie-associated fibrils and the protease-resistant protein (PrP_27–30), which are laboratory markers for the subacute spongiform encephalopathies. 1999 Farmers Weekly (Nexis) 9 July 88 We have recently succeeded in producing a protease resistant prion protein (considered to be the central feature of TSE) after exposing recombinant prion protein to manganese on the laboratory bench. This entry has been updated (OED Third Edition, June 2007; most recently modified version published online March 2022). < n.1903
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