proteasomen.

Brit.

/ˈprəʊtɪəsəʊm/, U.S.

/ˈproʊdiəˌsoʊm/

Forms:

α. 1900s– proteasome.

β. 1900s– proteosome.

Origin: Formed within English, by derivation. Etymons: protease n., proteinase n., -some comb. form, proteo- comb. form.

Etymology: < protea- (either in protease n. or < elements of proteinase n.) + -some comb. form. In β form < proteo- comb. form + -some comb. form. Compare slightly earlier prosome n.²

Cell Biology.

A complex of proteinases, found in eukaryotic cytoplasm and nuclei and also in some prokaryotes, which is involved in the degradation of intracellular proteins, esp. those tagged with ubiquitin.

ΚΠ

1988 A. P. Arrigo et al. in Nature 14 Jan. 331 The ‘prosome’ probably plays a critical role in intracellular protein breakdown, and we propose that it be renamed ‘proteasome’.

1992 Jrnl. Histochem. & Cytochem. 40 1165 The multicatalytic proteinase (MCP) prosome or proteasome..is believed to play a major role in non-lysosomal pathways of intracellular protein degradation and has recently been implicated in antigen processing.

1999 Mineral & Electrolyte Metabolism 25 220 In uremia, accelerated muscle protein degradation results from activation of the ATP-ubiquitin proteasome proteolytic pathway.

2002 Science 13 Sept. 1792/1 [Ubiquitin]..binds to other proteins, tagging them for destruction by a large multiprotein complex called the proteasome.

Derivatives

proteaˈsomal adj. of or relating to a proteasome.

ΚΠ

1989 Biochem. & Biophysical Res. Communications 158 548 On addition of urea they were degraded autocatalytically in a time- and dose-dependent manner, suggesting that destruction of the proteasomal complexes acts as a signal for their autolysis.

2002 Proc. National Acad. Sci. U.S.A. 99 14346/1 Binding of the 19S regulatory particle confers protein-degrading onto the 20S complex, which is essential for proteasomal functioning.

This is a new entry (OED Third Edition, June 2007; most recently modified version published online March 2022).

单词	proteasome
释义	proteasomen. Brit. /ˈprəʊtɪəsəʊm/, U.S. /ˈproʊdiəˌsoʊm/ Forms: α. 1900s– proteasome. β. 1900s– proteosome. Origin: Formed within English, by derivation. Etymons: protease n., proteinase n., -some comb. form, proteo- comb. form. Etymology: < protea- (either in protease n. or < elements of proteinase n.) + -some comb. form. In β form < proteo- comb. form + -some comb. form. Compare slightly earlier prosome n.² Cell Biology. A complex of proteinases, found in eukaryotic cytoplasm and nuclei and also in some prokaryotes, which is involved in the degradation of intracellular proteins, esp. those tagged with ubiquitin. ΚΠ 1988 A. P. Arrigo et al. in Nature 14 Jan. 331 The ‘prosome’ probably plays a critical role in intracellular protein breakdown, and we propose that it be renamed ‘proteasome’. 1992 Jrnl. Histochem. & Cytochem. 40 1165 The multicatalytic proteinase (MCP) prosome or proteasome..is believed to play a major role in non-lysosomal pathways of intracellular protein degradation and has recently been implicated in antigen processing. 1999 Mineral & Electrolyte Metabolism 25 220 In uremia, accelerated muscle protein degradation results from activation of the ATP-ubiquitin proteasome proteolytic pathway. 2002 Science 13 Sept. 1792/1 [Ubiquitin]..binds to other proteins, tagging them for destruction by a large multiprotein complex called the proteasome. Derivatives proteaˈsomal adj. of or relating to a proteasome. ΚΠ 1989 Biochem. & Biophysical Res. Communications 158 548 On addition of urea they were degraded autocatalytically in a time- and dose-dependent manner, suggesting that destruction of the proteasomal complexes acts as a signal for their autolysis. 2002 Proc. National Acad. Sci. U.S.A. 99 14346/1 Binding of the 19S regulatory particle confers protein-degrading onto the 20S complex, which is essential for proteasomal functioning. This is a new entry (OED Third Edition, June 2007; most recently modified version published online March 2022). < n.1988
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